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mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease.
Wege AK, Rom-Jurek EM, Jank P, Denkert C, Ugocsai P, Solbach C, Blohmer JU, Sinn B, van Mackelenbergh M, Möbus V, Trumpp A, Marangoni E, Pfarr N, Irlbeck C, Warfsmann J, Polzer B, Weber F, Ortmann O, Loibl S, Vladimirova V, Brockhoff G. Wege AK, et al. Among authors: irlbeck c. Int J Cancer. 2022 Apr 15;150(8):1357-1372. doi: 10.1002/ijc.33911. Epub 2021 Dec 28. Int J Cancer. 2022. PMID: 34927257
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Werner-Klein M, Grujovic A, Irlbeck C, Obradović M, Hoffmann M, Koerkel-Qu H, Lu X, Treitschke S, Köstler C, Botteron C, Weidele K, Werno C, Polzer B, Kirsch S, Gužvić M, Warfsmann J, Honarnejad K, Czyz Z, Feliciello G, Blochberger I, Grunewald S, Schneider E, Haunschild G, Patwary N, Guetter S, Huber S, Rack B, Harbeck N, Buchholz S, Rümmele P, Heine N, Rose-John S, Klein CA. Werner-Klein M, et al. Among authors: irlbeck c. Nat Commun. 2020 Oct 5;11(1):4977. doi: 10.1038/s41467-020-18701-4. Nat Commun. 2020. PMID: 33020483 Free PMC article.