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In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer.
Lau LMS, Mayoh C, Xie J, Barahona P, MacKenzie KL, Wong M, Kamili A, Tsoli M, Failes TW, Kumar A, Mould EVA, Gifford A, Chow SO, Pinese M, Fletcher JI, Arndt GM, Khuong-Quang DA, Wadham C, Batey D, Eden G, Trebilcock P, Joshi S, Alfred S, Gopalakrishnan A, Khan A, Grebert Wade D, Strong PA, Manouvrier E, Morgan LT, Span M, Lim JY, Cadiz R, Ung C, Thomas DM, Tucker KM, Warby M, McCowage GB, Dalla-Pozza L, Byrne JA, Saletta F, Fellowes A, Fox SB, Norris MD, Tyrrell V, Trahair TN, Lock RB, Cowley MJ, Ekert PG, Haber M, Ziegler DS, Marshall GM. Lau LMS, et al. Among authors: kamili a. EMBO Mol Med. 2022 Apr 7;14(4):e14608. doi: 10.15252/emmm.202114608. Epub 2021 Dec 20. EMBO Mol Med. 2022. PMID: 34927798 Free PMC article.
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.
Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M. Gamble LD, et al. Among authors: kamili a. Sci Transl Med. 2019 Jan 30;11(477):eaau1099. doi: 10.1126/scitranslmed.aau1099. Sci Transl Med. 2019. PMID: 30700572
CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth.
Huynh T, Murray J, Flemming CL, Kamili A, Hofmann U, Cheung L, Roundhill EA, Yu DMT, Webber HT, Schwab M, Henderson MJ, Haber M, Norris MD, Fletcher JI. Huynh T, et al. Among authors: kamili a. Biochem Pharmacol. 2020 Feb;172:113770. doi: 10.1016/j.bcp.2019.113770. Epub 2019 Dec 17. Biochem Pharmacol. 2020. PMID: 31862449
Mouse models of high-risk neuroblastoma.
Kamili A, Atkinson C, Trahair TN, Fletcher JI. Kamili A, et al. Cancer Metastasis Rev. 2020 Mar;39(1):261-274. doi: 10.1007/s10555-020-09855-0. Cancer Metastasis Rev. 2020. PMID: 31989509 Review.
Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression.
Gao J, Jung M, Mayoh C, Venkat P, Hannan KM, Fletcher JI, Kamili A, Gifford AJ, Kusnadi EP, Pearson RB, Hannan RD, Haber M, Norris MD, Somers K, Henderson MJ. Gao J, et al. Among authors: kamili a. Cancer Res. 2020 Sep 1;80(17):3706-3718. doi: 10.1158/0008-5472.CAN-19-3914. Epub 2020 Jul 10. Cancer Res. 2020. PMID: 32651259
Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy.
Chen J, Nelson C, Wong M, Tee AE, Liu PY, La T, Fletcher JI, Kamili A, Mayoh C, Bartenhagen C, Trahair TN, Xu N, Jayatilleke N, Wong M, Peng H, Atmadibrata B, Cheung BB, Lan Q, Bryan TM, Mestdagh P, Vandesompele J, Combaret V, Boeva V, Wang JY, Janoueix-Lerosey I, Cowley MJ, MacKenzie KL, Dolnikov A, Li J, Polly P, Marshall GM, Reddel RR, Norris MD, Haber M, Fischer M, Zhang XD, Pickett HA, Liu T. Chen J, et al. Among authors: kamili a. Clin Cancer Res. 2021 Mar 1;27(5):1438-1451. doi: 10.1158/1078-0432.CCR-20-3044. Epub 2020 Dec 11. Clin Cancer Res. 2021. PMID: 33310889
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Grohmann C, Walker F, Devlin M, Luo MX, Chüeh AC, Doherty J, Vaillant F, Ho GY, Wakefield MJ, Weeden CE, Kamili A, Murray J, Po'uha ST, Weinstock J, Kane SR, Faux MC, Broekhuizen E, Zheng Y, Shield-Artin K, Kershaw NJ, Tan CW, Witchard HM, Ebert G, Charman SA, Street I, Kavallaris M, Haber M, Fletcher JI, Asselin-Labat ML, Scott CL, Visvader JE, Lindeman GJ, Watson KG, Burgess AW, Lessene G. Grohmann C, et al. Among authors: kamili a. Cell Death Dis. 2021 Mar 12;12(3):268. doi: 10.1038/s41419-020-03269-0. Cell Death Dis. 2021. PMID: 33712556 Free PMC article.
77 results