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Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.
Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengdelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Grenegård M. Kardeby C, et al. Among authors: sun y. Blood Adv. 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950. Blood Adv. 2019. PMID: 30700416 Free PMC article.
Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.
Vandenbriele C, Sun Y, Criel M, Cludts K, Van Kerckhoven S, Izzi B, Vanassche T, Verhamme P, Hoylaerts MF. Vandenbriele C, et al. Among authors: sun y. Platelets. 2016 Jun;27(4):365-72. doi: 10.3109/09537104.2015.1111321. Epub 2015 Nov 30. Platelets. 2016. PMID: 26619766 Free article.
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