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Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis.
Gopalsamuthiram V, Kadam AL, Noble JK, Snead DR, Williams C, Jamison TF, Senanayake C, Yadaw AK, Roy S, Sirasani G, Gupton BF, Burns J, Cook DW, Stringham RW, Ahmad S, Krack R. Gopalsamuthiram V, et al. Among authors: burns j. Org Process Res Dev. 2021 Dec 17;25(12):2679-2685. doi: 10.1021/acs.oprd.1c00219. Epub 2021 Dec 9. Org Process Res Dev. 2021. PMID: 34955627 Free PMC article. Review.
Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832.
Gopalsamuthiram V, Ho DB, Peck CL, Natarajan V, Agrawal T, Burns JM, Bachert J, Cook DW, Stringham RW, Nelson R, Ahmad S, Gupton BF, Snead DR, McQuade DT, Vaidyanathan R, Donsbach K, Sieber JD. Gopalsamuthiram V, et al. Among authors: burns jm. ACS Omega. 2022 Feb 18;7(8):7223-7228. doi: 10.1021/acsomega.1c06996. eCollection 2022 Mar 1. ACS Omega. 2022. PMID: 35252712 Free PMC article.
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223.
Cardoso FSP, Kadam AL, Nelson RC, Tomlin JW, Dahal D, Kuehner CS, Gudvangen G, Arduengo AJ 3rd, Burns JM, Aleshire SL, Snead DR, Qu F, Belmore K, Ahmad S, Agrawal T, Sieber JD, Donsbach KO. Cardoso FSP, et al. Among authors: burns jm. Org Process Res Dev. 2023 Jul 12;27(7):1390-1399. doi: 10.1021/acs.oprd.3c00148. eCollection 2023 Jul 21. Org Process Res Dev. 2023. PMID: 37496954 Free PMC article.
A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid.
Kalmode HP, Ravikumar O, Paymode DJ, Bachert J, Burns JM, Stringham RW, Aleshire SL, Nelson RC. Kalmode HP, et al. Among authors: burns jm. Org Process Res Dev. 2024 Mar 27;28(4):1195-1204. doi: 10.1021/acs.oprd.4c00014. eCollection 2024 Apr 19. Org Process Res Dev. 2024. PMID: 38660380 Free PMC article.
Synthetic Process Development of (R)-(+)-1,2-Epoxy-5-hexene: An Important Chiral Building Block.
Guthrie D, Saathoff JM, Sahani RL, Nunes De Souza A, Cook DW, Hochstetler SR, Burns JM, Moazeni-Pourasil RS, Wierzbicki J, Ahmad S, Laidlaw GM, Gupton BF, Shanahan CS, Klumpp DA, Jin L. Guthrie D, et al. Among authors: burns jm. Org Process Res Dev. 2024 Aug 1;28(8):3197-3205. doi: 10.1021/acs.oprd.4c00101. eCollection 2024 Aug 16. Org Process Res Dev. 2024. PMID: 39171130 Free PMC article.
4,725 results