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Emerging Role of Electron Microscopy in Drug Discovery.
Johnson RM, Higgins AJ, Muench SP. Johnson RM, et al. Among authors: higgins aj. Trends Biochem Sci. 2019 Oct;44(10):897-898. doi: 10.1016/j.tibs.2019.07.003. Epub 2019 Aug 10. Trends Biochem Sci. 2019. PMID: 31409563 Free article. Review. No abstract available.
Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation.
Hesketh SJ, Klebl DP, Higgins AJ, Thomsen M, Pickles IB, Sobott F, Sivaprasadarao A, Postis VLG, Muench SP. Hesketh SJ, et al. Among authors: higgins aj. Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183192. doi: 10.1016/j.bbamem.2020.183192. Epub 2020 Jan 13. Biochim Biophys Acta Biomembr. 2020. PMID: 31945320 Free PMC article.
Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs.
Iadanza MG, Schiffrin B, White P, Watson MA, Horne JE, Higgins AJ, Calabrese AN, Brockwell DJ, Tuma R, Kalli AC, Radford SE, Ranson NA. Iadanza MG, et al. Among authors: higgins aj. Commun Biol. 2020 Dec 14;3(1):766. doi: 10.1038/s42003-020-01419-w. Commun Biol. 2020. PMID: 33318620 Free PMC article.
Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein.
Russell Lewis B, Uddin MR, Moniruzzaman M, Kuo KM, Higgins AJ, Shah LMN, Sobott F, Parks JM, Hammerschmid D, Gumbart JC, Zgurskaya HI, Reading E. Russell Lewis B, et al. Among authors: higgins aj. Nat Commun. 2023 Jul 18;14(1):3900. doi: 10.1038/s41467-023-39615-x. Nat Commun. 2023. PMID: 37463890 Free PMC article.
The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding.
White P, Haysom SF, Iadanza MG, Higgins AJ, Machin JM, Whitehouse JM, Horne JE, Schiffrin B, Carpenter-Platt C, Calabrese AN, Storek KM, Rutherford ST, Brockwell DJ, Ranson NA, Radford SE. White P, et al. Among authors: higgins aj. Nat Commun. 2021 Jul 7;12(1):4174. doi: 10.1038/s41467-021-24432-x. Nat Commun. 2021. PMID: 34234105 Free PMC article.
112 results