Hastings ML - Search Results

1

Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis.

Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML. Michaels WE, et al. Among authors: hastings ml. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114886119. doi: 10.1073/pnas.2114886119. Proc Natl Acad Sci U S A. 2022. PMID: 35017302 Free PMC article.

2

Targeting RNA splicing for disease therapy.

Havens MA, Duelli DM, Hastings ML. Havens MA, et al. Among authors: hastings ml. Wiley Interdiscip Rev RNA. 2013 May-Jun;4(3):247-66. doi: 10.1002/wrna.1158. Epub 2013 Mar 19. Wiley Interdiscip Rev RNA. 2013. PMID: 23512601 Free PMC article. Review.

3

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML. Hinrich AJ, et al. Among authors: hastings ml. EMBO Mol Med. 2016 Apr 1;8(4):328-45. doi: 10.15252/emmm.201505846. EMBO Mol Med. 2016. PMID: 26902204 Free PMC article.

4

Splice-switching antisense oligonucleotides as therapeutic drugs.

Havens MA, Hastings ML. Havens MA, et al. Among authors: hastings ml. Nucleic Acids Res. 2016 Aug 19;44(14):6549-63. doi: 10.1093/nar/gkw533. Epub 2016 Jun 10. Nucleic Acids Res. 2016. PMID: 27288447 Free PMC article. Review.

5

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse.

Depreux FF, Wang L, Jiang H, Jodelka FM, Rosencrans RF, Rigo F, Lentz JJ, Brigande JV, Hastings ML. Depreux FF, et al. Among authors: hastings ml. Nucleic Acids Res. 2016 Nov 16;44(20):9519-9529. doi: 10.1093/nar/gkw867. Epub 2016 Sep 28. Nucleic Acids Res. 2016. PMID: 27683224 Free PMC article.

6

Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.

Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. Chang JL, et al. Among authors: hastings ml. Mol Ther. 2018 Jun 6;26(6):1539-1551. doi: 10.1016/j.ymthe.2018.02.029. Epub 2018 Mar 6. Mol Ther. 2018. PMID: 29628304 Free PMC article.

7

Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction.

Hastings ML, Jones TA. Hastings ML, et al. Neurotherapeutics. 2019 Apr;16(2):348-359. doi: 10.1007/s13311-019-00729-0. Neurotherapeutics. 2019. PMID: 30972560 Free PMC article. Review.

8

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells.

Michaels WE, Bridges RJ, Hastings ML. Michaels WE, et al. Among authors: hastings ml. Nucleic Acids Res. 2020 Jul 27;48(13):7454-7467. doi: 10.1093/nar/gkaa490. Nucleic Acids Res. 2020. PMID: 32520327 Free PMC article.

9

Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease.

Centa JL, Jodelka FM, Hinrich AJ, Johnson TB, Ochaba J, Jackson M, Duelli DM, Weimer JM, Rigo F, Hastings ML. Centa JL, et al. Among authors: hastings ml. Nat Med. 2020 Sep;26(9):1444-1451. doi: 10.1038/s41591-020-0986-1. Epub 2020 Jul 27. Nat Med. 2020. PMID: 32719489 Free PMC article.

10

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice.

Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Korecka JA, et al. Among authors: hastings ml. Mol Ther Nucleic Acids. 2020 Sep 4;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Epub 2020 Jun 27. Mol Ther Nucleic Acids. 2020. PMID: 32736291 Free PMC article.

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