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Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells.
Kakade P, Ojha H, Raimi OG, Shaw A, Waddell AD, Ault JR, Burel S, Brockmann K, Kumar A, Ahangar MS, Krysztofinska EM, Macartney T, Bayliss R, Fitzgerald JC, Muqit MMK. Kakade P, et al. Among authors: fitzgerald jc. Open Biol. 2022 Jan;12(1):210264. doi: 10.1098/rsob.210264. Epub 2022 Jan 19. Open Biol. 2022. PMID: 35042401 Free PMC article.
Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.
Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R. Burbulla LF, et al. Among authors: fitzgerald jc. Cell Death Dis. 2014 Apr 17;5(4):e1180. doi: 10.1038/cddis.2014.103. Cell Death Dis. 2014. PMID: 24743735 Free PMC article.
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.
Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R. Fitzgerald JC, et al. Brain. 2017 Sep 1;140(9):2444-2459. doi: 10.1093/brain/awx202. Brain. 2017. PMID: 29050400
239 results