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The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.
Ihle NT, Paine-Murrieta G, Berggren MI, Baker A, Tate WR, Wipf P, Abraham RT, Kirkpatrick DL, Powis G. Ihle NT, et al. Among authors: wipf p. Mol Cancer Ther. 2005 Sep;4(9):1349-57. doi: 10.1158/1535-7163.MCT-05-0149. Mol Cancer Ther. 2005. PMID: 16170026 Free PMC article.
Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.
Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, Wang Z. Johnston PA, et al. Among authors: wipf p. Assay Drug Dev Technol. 2016 May;14(4):226-39. doi: 10.1089/adt.2016.716. Assay Drug Dev Technol. 2016. PMID: 27187604 Free PMC article.
Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer.
Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P. Johnson JK, et al. Among authors: wipf p. ACS Med Chem Lett. 2016 May 27;7(8):785-90. doi: 10.1021/acsmedchemlett.6b00186. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563404 Free PMC article.
Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.
Masoodi KZ, Eisermann K, Yang Z, Dar JA, Pascal LE, Nguyen M, O'Malley K, Parrinello E, Feturi FG, Kenefake AN, Nelson JB, Johnston PA, Wipf P, Wang Z. Masoodi KZ, et al. Among authors: wipf p. Endocrinology. 2017 Oct 1;158(10):3152-3161. doi: 10.1210/en.2017-00408. Endocrinology. 2017. PMID: 28977599 Free PMC article.
460 results