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Interplay between K-RAS and miRNAs.
Shui B, La Rocca G, Ventura A, Haigis KM. Shui B, et al. Among authors: ventura a. Trends Cancer. 2022 May;8(5):384-396. doi: 10.1016/j.trecan.2022.01.002. Epub 2022 Jan 31. Trends Cancer. 2022. PMID: 35093302 Free PMC article. Review.
In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.
La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB. La Rocca G, et al. Among authors: ventura a. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72. doi: 10.1073/pnas.1424217112. Epub 2015 Jan 7. Proc Natl Acad Sci U S A. 2015. PMID: 25568082 Free PMC article.
High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.
Li X, Pritykin Y, Concepcion CP, Lu Y, La Rocca G, Zhang M, King B, Cook PJ, Au YW, Popow O, Paulo JA, Otis HG, Mastroleo C, Ogrodowski P, Schreiner R, Haigis KM, Betel D, Leslie CS, Ventura A. Li X, et al. Among authors: ventura a. Mol Cell. 2020 Jul 2;79(1):167-179.e11. doi: 10.1016/j.molcel.2020.05.009. Epub 2020 Jun 3. Mol Cell. 2020. PMID: 32497496 Free PMC article.
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.
Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP 4th, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho YJ, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. Escobar-Hoyos LF, et al. Among authors: ventura a. Cancer Cell. 2020 Aug 10;38(2):198-211.e8. doi: 10.1016/j.ccell.2020.05.010. Epub 2020 Jun 18. Cancer Cell. 2020. PMID: 32559497 Free PMC article.
Inducible and reversible inhibition of miRNA-mediated gene repression in vivo.
La Rocca G, King B, Shui B, Li X, Zhang M, Akat KM, Ogrodowski P, Mastroleo C, Chen K, Cavalieri V, Ma Y, Anelli V, Betel D, Vidigal J, Tuschl T, Meister G, Thompson CB, Lindsten T, Haigis K, Ventura A. La Rocca G, et al. Among authors: ventura a. Elife. 2021 Aug 31;10:e70948. doi: 10.7554/eLife.70948. Elife. 2021. PMID: 34463618 Free PMC article.
Engineered extrachromosomal oncogene amplifications promote tumorigenesis.
Pradella D, Zhang M, Gao R, Yao MA, Gluchowska KM, Cendon-Florez Y, Mishra T, La Rocca G, Weigl M, Jiao Z, Nguyen HHM, Lisi M, Ozimek MM, Mastroleo C, Chen K, Grimm F, Luebeck J, Zhang S, Zolli AA, Sun EG, Dameracharla B, Zhao Z, Pritykin Y, Sigel C, Chang HY, Mischel PS, Bafna V, Antonescu CR, Ventura A. Pradella D, et al. Among authors: ventura a. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08318-8. Online ahead of print. Nature. 2024. PMID: 39695225
1,458 results