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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Among authors: luuk h. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
Evidence for impaired function of dopaminergic system in Wfs1-deficient mice.
Visnapuu T, Plaas M, Reimets R, Raud S, Terasmaa A, Kõks S, Sütt S, Luuk H, Hundahl CA, Eskla KL, Altpere A, Alttoa A, Harro J, Vasar E. Visnapuu T, et al. Among authors: luuk h. Behav Brain Res. 2013 May 1;244:90-9. doi: 10.1016/j.bbr.2013.01.046. Epub 2013 Feb 8. Behav Brain Res. 2013. PMID: 23396150
Hypothermia augments stress response in mammalian cells.
Eskla KL, Porosk R, Reimets R, Visnapuu T, Vasar E, Hundahl CA, Luuk H. Eskla KL, et al. Among authors: luuk h. Free Radic Biol Med. 2018 Jun;121:157-168. doi: 10.1016/j.freeradbiomed.2018.04.571. Epub 2018 Apr 25. Free Radic Biol Med. 2018. PMID: 29704622 Free article.
VHL-deficiency leads to reductive stress in renal cells.
Vellama H, Eskla KL, Eichelmann H, Hüva A, Tennant DA, Thakker A, Roberts J, Jagomäe T, Porosk R, Laisk A, Oja V, Rämma H, Volke V, Vasar E, Luuk H. Vellama H, et al. Among authors: luuk h. Free Radic Biol Med. 2023 Nov 1;208:1-12. doi: 10.1016/j.freeradbiomed.2023.07.029. Epub 2023 Jul 26. Free Radic Biol Med. 2023. PMID: 37506952 Free PMC article.
30 results