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Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer.
Akıncılar SC, Chua JYH, Ng QF, Chan CHT, Eslami-S Z, Chen K, Low JL, Arumugam S, Aswad L, Chua C, Tan IB, DasGupta R, Fullwood MJ, Tergaonkar V. Akıncılar SC, et al. Among authors: chen k. Nucleic Acids Res. 2023 Jan 11;51(1):1-16. doi: 10.1093/nar/gkac479. Nucleic Acids Res. 2023. PMID: 35697349 Free PMC article.
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.
Zhang Y, Chen K, Tang SC, Cai Y, Nambu A, See YX, Fu C, Raju A, Lebeau B, Ling Z, Chan JJ, Tay Y, Mutwil M, Lakshmanan M, Tucker-Kellogg G, Chng WJ, Tenen DG, Osato M, Tergaonkar V, Fullwood MJ. Zhang Y, et al. Among authors: chen k. Nat Struct Mol Biol. 2024 Sep 20. doi: 10.1038/s41594-024-01391-7. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 39304765
Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol.
Gao R, Yue B, Lv C, Geng X, Yu Z, Wang H, Zhang B, Ai F, Wang Z, Liu D, Wang Z, Chen K, Dou W. Gao R, et al. Among authors: chen k. Acta Pharm Sin B. 2024 Dec;14(12):5286-5304. doi: 10.1016/j.apsb.2024.09.018. Epub 2024 Oct 18. Acta Pharm Sin B. 2024. PMID: 39807321 Free PMC article.
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