Rörsch F - Search Results

1

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport.

Kahnt AS, Angioni C, Göbel T, Hofmann B, Roos J, Steinbrink SD, Rörsch F, Thomas D, Geisslinger G, Zacharowski K, Grösch S, Steinhilber D, Maier TJ. Kahnt AS, et al. Among authors: rorsch f. Front Pharmacol. 2022 Jan 21;12:782584. doi: 10.3389/fphar.2021.782584. eCollection 2021. Front Pharmacol. 2022. PMID: 35126121 Free PMC article.

2

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity.

Kahnt AS, Rörsch F, Diehl O, Hofmann B, Lehmann C, Steinbrink SD, Angioni C, Geisslinger G, Grösch S, Steinhilber D, Maier TJ. Kahnt AS, et al. Among authors: rorsch f. Biochem Pharmacol. 2013 Jul 15;86(2):286-96. doi: 10.1016/j.bcp.2013.05.005. Epub 2013 May 14. Biochem Pharmacol. 2013. PMID: 23684692

3

Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor.

Wisniewska JM, Rödl CB, Kahnt AS, Buscató El, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B. Wisniewska JM, et al. Among authors: rorsch f. Biochem Pharmacol. 2012 Jan 15;83(2):228-40. doi: 10.1016/j.bcp.2011.10.012. Epub 2011 Oct 18. Biochem Pharmacol. 2012. PMID: 22027220

4

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

Rörsch F, Buscató E, Deckmann K, Schneider G, Schubert-Zsilavecz M, Geisslinger G, Proschak E, Grösch S. Rörsch F, et al. J Med Chem. 2012 Apr 26;55(8):3792-803. doi: 10.1021/jm201687d. Epub 2012 Apr 11. J Med Chem. 2012. PMID: 22449023

5

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.

Rörsch F, Wobst I, Zettl H, Schubert-Zsilavecz M, Grösch S, Geisslinger G, Schneider G, Proschak E. Rörsch F, et al. J Med Chem. 2010 Jan 28;53(2):911-5. doi: 10.1021/jm9012505. J Med Chem. 2010. PMID: 20025212

6

Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB.

Deckmann K, Rörsch F, Steri R, Schubert-Zsilavecz M, Geisslinger G, Grösch S. Deckmann K, et al. Among authors: rorsch f. Biochem Pharmacol. 2010 Nov 1;80(9):1365-72. doi: 10.1016/j.bcp.2010.07.032. Epub 2010 Aug 3. Biochem Pharmacol. 2010. PMID: 20688046 Free article.

7

Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1.

Deckmann K, Rörsch F, Geisslinger G, Grösch S. Deckmann K, et al. Among authors: rorsch f. Cell Signal. 2012 Feb;24(2):460-467. doi: 10.1016/j.cellsig.2011.09.025. Epub 2011 Oct 1. Cell Signal. 2012. PMID: 21983014

8

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

Buscató El, Wisniewska JM, Rödl CB, Brüggerhoff A, Kaiser A, Rörsch F, Kostewicz E, Wurglics M, Schubert-Zsilavecz M, Grösch S, Steinhilber D, Hofmann B, Proschak E. Buscató El, et al. Among authors: rorsch f. Future Med Chem. 2013 May;5(8):865-80. doi: 10.4155/fmc.13.72. Future Med Chem. 2013. PMID: 23682565

9

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

Hanke T, Rörsch F, Thieme TM, Ferreiros N, Schneider G, Geisslinger G, Proschak E, Grösch S, Schubert-Zsilavecz M. Hanke T, et al. Among authors: rorsch f. Bioorg Med Chem. 2013 Dec 15;21(24):7874-83. doi: 10.1016/j.bmc.2013.10.006. Epub 2013 Oct 16. Bioorg Med Chem. 2013. PMID: 24183739

10

Identification of DNA-protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system.

Deckmann K, Rörsch F, Geisslinger G, Grösch S. Deckmann K, et al. Among authors: rorsch f. Mol Biosyst. 2012 Apr;8(5):1389-95. doi: 10.1039/c2mb05500g. Epub 2012 Feb 22. Mol Biosyst. 2012. PMID: 22358373

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