Roepe PD - Search Results

1

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.

Small-Saunders JL, Hagenah LM, Wicht KJ, Dhingra SK, Deni I, Kim J, Vendome J, Gil-Iturbe E, Roepe PD, Mehta M, Mancia F, Quick M, Eppstein MJ, Fidock DA. Small-Saunders JL, et al. Among authors: roepe pd. PLoS Pathog. 2022 Feb 7;18(2):e1010278. doi: 10.1371/journal.ppat.1010278. eCollection 2022 Feb. PLoS Pathog. 2022. PMID: 35130315 Free PMC article.

2

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Fidock DA, et al. Among authors: roepe pd. Mol Cell. 2000 Oct;6(4):861-71. doi: 10.1016/s1097-2765(05)00077-8. Mol Cell. 2000. PMID: 11090624 Free PMC article.

3

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Mehlotra RK, et al. Among authors: roepe pd. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12689-94. doi: 10.1073/pnas.221440898. Proc Natl Acad Sci U S A. 2001. PMID: 11675500 Free PMC article.

4

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Cooper RA, et al. Among authors: roepe pd. Mol Pharmacol. 2002 Jan;61(1):35-42. doi: 10.1124/mol.61.1.35. Mol Pharmacol. 2002. PMID: 11752204

5

Chloroquine resistance in the malarial parasite, Plasmodium falciparum.

Ursos LM, Roepe PD. Ursos LM, et al. Among authors: roepe pd. Med Res Rev. 2002 Sep;22(5):465-91. doi: 10.1002/med.10016. Med Res Rev. 2002. PMID: 12210555 Review.

6

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA. Waller KL, et al. Among authors: roepe pd. J Biol Chem. 2003 Aug 29;278(35):33593-601. doi: 10.1074/jbc.M302215200. Epub 2003 Jun 17. J Biol Chem. 2003. PMID: 12813054 Free article.

7

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

Bennett TN, Kosar AD, Ursos LM, Dzekunov S, Singh Sidhu AB, Fidock DA, Roepe PD. Bennett TN, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2004 Jan;133(1):99-114. doi: 10.1016/j.molbiopara.2003.09.008. Mol Biochem Parasitol. 2004. PMID: 14668017

8

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.

Zhang H, Paguio M, Roepe PD. Zhang H, et al. Among authors: roepe pd. Biochemistry. 2004 Jul 6;43(26):8290-6. doi: 10.1021/bi049137i. Biochemistry. 2004. PMID: 15222741

9

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. Reeves DC, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2006 Dec;150(2):288-99. doi: 10.1016/j.molbiopara.2006.09.001. Epub 2006 Sep 25. Mol Biochem Parasitol. 2006. PMID: 17014918 Free PMC article.

10

Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance.

Bennett TN, Patel J, Ferdig MT, Roepe PD. Bennett TN, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2007 May;153(1):48-58. doi: 10.1016/j.molbiopara.2007.01.018. Epub 2007 Feb 8. Mol Biochem Parasitol. 2007. PMID: 17353059 Free PMC article.

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