Ravichandran K - Search Results

1

Ribonucleotide reductase, a novel drug target for gonorrhea.

Narasimhan J, Letinski S, Jung SP, Gerasyuto A, Wang J, Arnold M, Chen G, Hedrick J, Dumble M, Ravichandran K, Levitz T, Cui C, Drennan CL, Stubbe J, Karp G, Branstrom A. Narasimhan J, et al. Among authors: ravichandran k. Elife. 2022 Feb 9;11:e67447. doi: 10.7554/eLife.67447. Elife. 2022. PMID: 35137690 Free PMC article.

2

Spectroscopic Evidence for a H Bond Network at Y₃₅₆ Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase.

Nick TU, Ravichandran KR, Stubbe J, Kasanmascheff M, Bennati M. Nick TU, et al. Biochemistry. 2017 Jul 18;56(28):3647-3656. doi: 10.1021/acs.biochem.7b00462. Epub 2017 Jul 7. Biochemistry. 2017. PMID: 28640584

3

Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay.

Ravichandran K, Olshansky L, Nocera DG, Stubbe J. Ravichandran K, et al. Biochemistry. 2020 Apr 14;59(14):1442-1453. doi: 10.1021/acs.biochem.0c00001. Epub 2020 Mar 30. Biochemistry. 2020. PMID: 32186371 Free PMC article.

4

Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer.

Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J. Lin Q, et al. Among authors: ravichandran k. J Biol Chem. 2017 Jun 2;292(22):9229-9239. doi: 10.1074/jbc.M117.783092. Epub 2017 Apr 4. J Biol Chem. 2017. PMID: 28377505 Free PMC article.

5

Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase.

Ravichandran KR, Minnihan EC, Wei Y, Nocera DG, Stubbe J. Ravichandran KR, et al. J Am Chem Soc. 2015 Nov 18;137(45):14387-95. doi: 10.1021/jacs.5b09189. Epub 2015 Nov 4. J Am Chem Soc. 2015. PMID: 26492582 Free PMC article.

6

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.

Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J. Oyala PH, et al. J Am Chem Soc. 2016 Jun 29;138(25):7951-64. doi: 10.1021/jacs.6b03605. Epub 2016 Jun 21. J Am Chem Soc. 2016. PMID: 27276098 Free PMC article.

7

A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes.

Ravichandran KR, Taguchi AT, Wei Y, Tommos C, Nocera DG, Stubbe J. Ravichandran KR, et al. J Am Chem Soc. 2016 Oct 19;138(41):13706-13716. doi: 10.1021/jacs.6b08200. Epub 2016 Oct 7. J Am Chem Soc. 2016. PMID: 28068088 Free PMC article.

8

Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.

Ravichandran K, Minnihan EC, Lin Q, Yokoyama K, Taguchi AT, Shao J, Nocera DG, Stubbe J. Ravichandran K, et al. Biochemistry. 2017 Feb 14;56(6):856-868. doi: 10.1021/acs.biochem.6b01145. Epub 2017 Feb 2. Biochemistry. 2017. PMID: 28103007 Free PMC article.

9

Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer.

Ravichandran KR, Liang L, Stubbe J, Tommos C. Ravichandran KR, et al. Biochemistry. 2013 Dec 10;52(49):8907-15. doi: 10.1021/bi401494f. Epub 2013 Nov 22. Biochemistry. 2013. PMID: 24228716 Free PMC article.

10

Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer.

Ravichandran KR, Zong AB, Taguchi AT, Nocera DG, Stubbe J, Tommos C. Ravichandran KR, et al. J Am Chem Soc. 2017 Mar 1;139(8):2994-3004. doi: 10.1021/jacs.6b11011. Epub 2017 Feb 21. J Am Chem Soc. 2017. PMID: 28171730 Free PMC article.

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