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Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Simpson DS, et al. Among authors: kashkar h. Immunity. 2022 Mar 8;55(3):423-441.e9. doi: 10.1016/j.immuni.2022.01.003. Epub 2022 Feb 8. Immunity. 2022. PMID: 35139355 Free PMC article.
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.
Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J. Gräb J, et al. Among authors: kashkar h. Nat Commun. 2019 Feb 8;10(1):688. doi: 10.1038/s41467-019-08405-9. Nat Commun. 2019. PMID: 30737374 Free PMC article.
Dimethylfumarate induces apoptosis in human mast cells.
Förster A, Preussner LM, Seeger JM, Rabenhorst A, Kashkar H, Mrowietz U, Hartmann K. Förster A, et al. Among authors: kashkar h. Exp Dermatol. 2013 Nov;22(11):719-24. doi: 10.1111/exd.12247. Exp Dermatol. 2013. PMID: 24112621
BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.
Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H. Andree M, et al. Among authors: kashkar h. EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23. EMBO J. 2014. PMID: 25056906 Free PMC article.
88 results