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119 results

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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Bhatt DP, Mills CA, Anderson KA, Henriques BJ, Lucas TG, Francisco S, Liu J, Ilkayeva OR, Adams AE, Kulkarni SR, Backos DS, Major MB, Grimsrud PA, Gomes CM, Hirschey MD. Bhatt DP, et al. Among authors: mills ca. J Biol Chem. 2022 Apr;298(4):101723. doi: 10.1016/j.jbc.2022.101723. Epub 2022 Feb 12. J Biol Chem. 2022. PMID: 35157847 Free PMC article.
Sensing Mitochondrial Acetyl-CoA to Tune Respiration.
Mills CA, Trub AG, Hirschey MD. Mills CA, et al. Trends Endocrinol Metab. 2019 Jan;30(1):1-3. doi: 10.1016/j.tem.2018.10.003. Epub 2018 Nov 12. Trends Endocrinol Metab. 2019. PMID: 30442533 Free PMC article. Review.
SETD2 maintains nuclear lamina stability to safeguard the genome.
Khan A, Metts JM, Collins LC, Mills CA, Li K, Brademeyer AL, Bowman BM, Major MB, Aubé J, Herring LE, Davis IJ, Strahl BD. Khan A, et al. Among authors: mills ca. bioRxiv [Preprint]. 2023 Sep 28:2023.09.28.560032. doi: 10.1101/2023.09.28.560032. bioRxiv. 2023. PMID: 37808753 Free PMC article. Preprint.
Developing forebrain synapses are uniquely vulnerable to sleep loss.
Gay SM, Chartampila E, Lord JS, Grizzard S, Maisashvili T, Ye M, Barker NK, Mordant AL, Mills CA, Herring LE, Diering GH. Gay SM, et al. Among authors: mills ca. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2407533121. doi: 10.1073/pnas.2407533121. Epub 2024 Oct 23. Proc Natl Acad Sci U S A. 2024. PMID: 39441640
Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton.
Mouery RD, Lukasik K, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Gupton SL, Emanuele MJ. Mouery RD, et al. Among authors: mills ca. Cell Rep. 2024 Aug 27;43(8):114510. doi: 10.1016/j.celrep.2024.114510. Epub 2024 Jul 16. Cell Rep. 2024. PMID: 39018246 Free PMC article.
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Tse EG, Stashko MA, Li K, Norris-Drouin JL, Herring LE, Mordant AL, Webb TS, Mills CA, Barker NK, Streblow ZJ, Perveen S, Arrowsmith CH, Couñago RM, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise MT, Willson TM, Popov KI, Pearce KH. Merten EM, et al. Among authors: mills ca. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2409166121. doi: 10.1073/pnas.2409166121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388272
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components.
Bashore FM, Foley CA, Ong HW, Rectenwald JM, Hanley RP, Norris-Drouin JL, Cholensky SH, Mills CA, Pearce KH, Herring LE, Kireev D, Frye SV, James LI. Bashore FM, et al. Among authors: mills ca. ACS Chem Biol. 2023 Mar 17;18(3):494-507. doi: 10.1021/acschembio.2c00804. Epub 2023 Mar 6. ACS Chem Biol. 2023. PMID: 36877831 Free PMC article.
119 results