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Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study.
Heijdra JM, Al Arashi W, de Jager NCB, Cloesmeijer ME, Bukkems LH, Zwaan CM, Leebeek FWG, Mathôt RAA, Cnossen MH; OPTI-CLOT Study Group. Heijdra JM, et al. Among authors: mathot raa. BMJ Open. 2022 Feb 15;12(2):e049493. doi: 10.1136/bmjopen-2021-049493. BMJ Open. 2022. PMID: 35168962 Free PMC article.
Positioning extended half-life concentrates for future use: a practical proposal.
Nederlof A, Mathôt RAA, Leebeek FWG, Fijnvandraat K, Fischer K, Cnossen MH; “OPTI-CLOT” study group. Nederlof A, et al. Among authors: mathot raa. Haemophilia. 2018 Sep;24(5):e369-e372. doi: 10.1111/hae.13588. Epub 2018 Aug 24. Haemophilia. 2018. PMID: 30144218 No abstract available.
Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: protocol for a multicentre single-armed trial, the DAVID study.
Schütte LM, Cnossen MH, van Hest RM, Driessens MHE, Fijnvandraat K, Polinder S, Beckers EAM, Coppens M, Eikenboom J, Laros-van Gorkom BAP, Meijer K, Nieuwenhuizen L, Mauser-Bunschoten EP, Leebeek FWG, Mathôt RAA, Kruip MJHA. Schütte LM, et al. Among authors: mathot raa. BMJ Open. 2019 Apr 23;9(4):e022719. doi: 10.1136/bmjopen-2018-022719. BMJ Open. 2019. PMID: 31015264 Free PMC article.
One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P® /Humate P® treatment in von Willebrand disease patients.
de Jager NCB, Bukkems LH, Heijdra JM, Hazendonk CHCAM, Fijnvandraat K, Meijer K, Eikenboom J, Laros-van Gorkom BAP, Leebeek FWG, Cnossen MH, Mathôt RAA; OPTI-CLOT group. de Jager NCB, et al. Among authors: mathot raa. J Thromb Haemost. 2020 Feb;18(2):295-305. doi: 10.1111/jth.14652. Epub 2019 Oct 21. J Thromb Haemost. 2020. PMID: 31557387 Free PMC article.
Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics.
Cloesmeijer ME, van den Oever HLA, Mathôt RAA, Zeeman M, Kruisdijk-Gerritsen A, Bles CMA, Nassikovker P, de Meijer AR, van Steveninck FL, Arbouw MEL. Cloesmeijer ME, et al. Among authors: mathot raa. Br J Clin Pharmacol. 2020 Aug;86(8):1620-1631. doi: 10.1111/bcp.14273. Epub 2020 Mar 29. Br J Clin Pharmacol. 2020. PMID: 32150285 Free PMC article.
A Novel, Enriched Population Pharmacokinetic Model for Recombinant Factor VIII-Fc Fusion Protein Concentrate in Hemophilia A Patients.
Bukkems LH, Heijdra JM, Mathias M, Collins PW, Hay CRM, Tait RC, Mangles S, Myers B, Evans G, Bailiff B, Curry N, Payne J, Austin S, Goedhart TMHJ, Leebeek FWG, Meijer K, Fijnvandraat K, Chowdary P, Mathôt RAA, Cnossen MH; for UK-EHL Outcomes Registry OPTI-CLOT Collaboration. Bukkems LH, et al. Among authors: mathot raa. Thromb Haemost. 2020 May;120(5):747-757. doi: 10.1055/s-0040-1709522. Epub 2020 May 5. Thromb Haemost. 2020. PMID: 32369846
234 results