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Anti-inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine.
Sudhakaran G, Prathap P, Guru A, Rajesh R, Sathish S, Madhavan T, Arasu MV, Al-Dhabi NA, Choi KC, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Cell Biol Int. 2022 May;46(5):771-791. doi: 10.1002/cbin.11769. Epub 2022 Feb 3. Cell Biol Int. 2022. PMID: 35077598
Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection.
Guru A, Sudhakaran G, Velayutham M, Murugan R, Pachaiappan R, Mothana RA, Noman OM, Juliet A, Arockiaraj J. Guru A, et al. Among authors: sudhakaran g. Comp Biochem Physiol C Toxicol Pharmacol. 2022 Aug;258:109364. doi: 10.1016/j.cbpc.2022.109364. Epub 2022 May 4. Comp Biochem Physiol C Toxicol Pharmacol. 2022. PMID: 35523404
Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model.
Sudhakaran G, Prathap P, Guru A, Haridevamuthu B, Murugan R, Almutairi BO, Almutairi MH, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Mol Cell Biochem. 2022 Oct;477(10):2387-2401. doi: 10.1007/s11010-022-04448-7. Epub 2022 May 16. Mol Cell Biochem. 2022. PMID: 35575874
Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism.
Singh M, Guru A, Sudhakaran G, Pachaiappan R, Mahboob S, Al-Ghanim KA, Al-Misned F, Juliet A, Gobi M, Arokiaraj J. Singh M, et al. Among authors: sudhakaran g. Comp Biochem Physiol C Toxicol Pharmacol. 2022 Dec;262:109463. doi: 10.1016/j.cbpc.2022.109463. Epub 2022 Sep 7. Comp Biochem Physiol C Toxicol Pharmacol. 2022. PMID: 36087706
Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels.
Sudhakaran G, Rajesh R, Guru A, Haridevamuthu B, Murugan R, Bhuvanesh N, Wadaan MA, Mahboob S, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Toxicol Appl Pharmacol. 2022 Nov 1;454:116229. doi: 10.1016/j.taap.2022.116229. Epub 2022 Sep 8. Toxicol Appl Pharmacol. 2022. PMID: 36089001
β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through phosphoenolpyruvate carboxykinase and insulin pathway in zebrafish in-vivo larval model.
Guru A, Sudhakaran G, Almutairi MH, Almutairi BO, Juliet A, Arockiaraj J. Guru A, et al. Among authors: sudhakaran g. Mol Biol Rep. 2022 Dec;49(12):11867-11879. doi: 10.1007/s11033-022-07882-4. Epub 2022 Oct 12. Mol Biol Rep. 2022. PMID: 36224446
67 results