Shah DK - Search Results

1

Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics.

Liu S, Shah DK. Liu S, et al. Among authors: shah dk. Drug Metab Dispos. 2022 Jun;50(6):867-878. doi: 10.1124/dmd.121.000460. Epub 2022 Feb 23. Drug Metab Dispos. 2022. PMID: 35197311 Free PMC article. Review.

2

A priori prediction of tumor payload concentrations: preclinical case study with an auristatin-based anti-5T4 antibody-drug conjugate.

Shah DK, King LE, Han X, Wentland JA, Zhang Y, Lucas J, Haddish-Berhane N, Betts A, Leal M. Shah DK, et al. AAPS J. 2014 May;16(3):452-63. doi: 10.1208/s12248-014-9576-9. Epub 2014 Mar 1. AAPS J. 2014. PMID: 24578215 Free PMC article.

3

Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development.

Singh AP, Shin YG, Shah DK. Singh AP, et al. Among authors: shah dk. Pharm Res. 2015 Nov;32(11):3508-25. doi: 10.1007/s11095-015-1626-1. Epub 2015 Feb 11. Pharm Res. 2015. PMID: 25666843 Review.

4

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

Shah DK. Shah DK. J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):553-71. doi: 10.1007/s10928-015-9447-8. Epub 2015 Sep 15. J Pharmacokinet Pharmacodyn. 2015. PMID: 26373957 Free PMC article. Review.

5

Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).

Singh AP, Shah DK. Singh AP, et al. Among authors: shah dk. AAPS J. 2017 Jul;19(4):1054-1070. doi: 10.1208/s12248-017-0071-y. Epub 2017 Apr 3. AAPS J. 2017. PMID: 28374319 Free PMC article.

6

Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.

Khot A, Tibbitts J, Rock D, Shah DK. Khot A, et al. Among authors: shah dk. AAPS J. 2017 Nov;19(6):1715-1734. doi: 10.1208/s12248-017-0131-3. Epub 2017 Aug 14. AAPS J. 2017. PMID: 28808917 Free PMC article.

7

Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE.

Singh AP, Shah DK. Singh AP, et al. Among authors: shah dk. Drug Metab Dispos. 2017 Nov;45(11):1120-1132. doi: 10.1124/dmd.117.076414. Epub 2017 Aug 18. Drug Metab Dispos. 2017. PMID: 28821484 Free PMC article.

8

Pharmacokinetics of protein and peptide conjugates.

Bumbaca B, Li Z, Shah DK. Bumbaca B, et al. Among authors: shah dk. Drug Metab Pharmacokinet. 2019 Feb;34(1):42-54. doi: 10.1016/j.dmpk.2018.11.001. Epub 2018 Nov 22. Drug Metab Pharmacokinet. 2019. PMID: 30573392 Free PMC article. Review.

9

Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice.

Khot A, Matsueda S, Thomas VA, Koya RC, Shah DK. Khot A, et al. Among authors: shah dk. J Pharmacol Exp Ther. 2019 Mar;368(3):503-513. doi: 10.1124/jpet.118.252858. Epub 2019 Jan 8. J Pharmacol Exp Ther. 2019. PMID: 30622170 Free PMC article.

10

Two-pore physiologically based pharmacokinetic model with de novo derived parameters for predicting plasma PK of different size protein therapeutics.

Li Z, Shah DK. Li Z, et al. Among authors: shah dk. J Pharmacokinet Pharmacodyn. 2019 Jun;46(3):305-318. doi: 10.1007/s10928-019-09639-2. Epub 2019 Apr 26. J Pharmacokinet Pharmacodyn. 2019. PMID: 31028591 Free PMC article.

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