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Prognostic Value of Serum Neurofilament Light Chain for Disease Activity and Worsening in Patients With Relapsing Multiple Sclerosis: Results From the Phase 3 ASCLEPIOS I and II Trials.
Ziemssen T, Arnold DL, Alvarez E, Cross AH, Willi R, Li B, Kukkaro P, Kropshofer H, Ramanathan K, Merschhemke M, Kieseier B, Su W, Häring DA, Hauser SL, Kappos L, Kuhle J. Ziemssen T, et al. Among authors: kropshofer h. Front Immunol. 2022 Mar 31;13:852563. doi: 10.3389/fimmu.2022.852563. eCollection 2022. Front Immunol. 2022. PMID: 35432382 Free PMC article.
Serum neurofilament light chain level associations with clinical and cognitive performance in multiple sclerosis: A longitudinal retrospective 5-year study.
Jakimovski D, Zivadinov R, Ramanthan M, Hagemeier J, Weinstock-Guttman B, Tomic D, Kropshofer H, Fuchs TA, Barro C, Leppert D, Yaldizli Ö, Kuhle J, Benedict RH. Jakimovski D, et al. Among authors: kropshofer h. Mult Scler. 2020 Nov;26(13):1670-1681. doi: 10.1177/1352458519881428. Epub 2019 Oct 15. Mult Scler. 2020. PMID: 31610732
Serum neurofilament light chain is a useful biomarker in pediatric multiple sclerosis.
Reinert MC, Benkert P, Wuerfel J, Michalak Z, Ruberte E, Barro C, Huppke P, Stark W, Kropshofer H, Tomic D, Leppert D, Kuhle J, Brück W, Gärtner J. Reinert MC, et al. Among authors: kropshofer h. Neurol Neuroimmunol Neuroinflamm. 2020 May 13;7(4):e749. doi: 10.1212/NXI.0000000000000749. Print 2020 Jul. Neurol Neuroimmunol Neuroinflamm. 2020. PMID: 32404429 Free PMC article.
Long-term prognostic value of longitudinal measurements of blood neurofilament levels.
Häring DA, Kropshofer H, Kappos L, Cohen JA, Shah A, Meinert R, Leppert D, Tomic D, Kuhle J. Häring DA, et al. Among authors: kropshofer h. Neurol Neuroimmunol Neuroinflamm. 2020 Aug 12;7(5):e856. doi: 10.1212/NXI.0000000000000856. Print 2020 Sep. Neurol Neuroimmunol Neuroinflamm. 2020. PMID: 32817406 Free PMC article. Clinical Trial.
Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis.
Chitnis T, Gonzalez C, Healy BC, Saxena S, Rosso M, Barro C, Michalak Z, Paul A, Kivisakk P, Diaz-Cruz C, Sattarnezhad N, Pierre IV, Glanz BI, Tomic D, Kropshofer H, Häring D, Leppert D, Kappos L, Bakshi R, Weiner HL, Kuhle J. Chitnis T, et al. Among authors: kropshofer h. Ann Clin Transl Neurol. 2018 Oct 16;5(12):1478-1491. doi: 10.1002/acn3.638. eCollection 2018 Dec. Ann Clin Transl Neurol. 2018. PMID: 30564615 Free PMC article.
Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.
Sormani MP, Haering DA, Kropshofer H, Leppert D, Kundu U, Barro C, Kappos L, Tomic D, Kuhle J. Sormani MP, et al. Among authors: kropshofer h. Ann Clin Transl Neurol. 2019 May 28;6(6):1081-1089. doi: 10.1002/acn3.795. eCollection 2019 Jun. Ann Clin Transl Neurol. 2019. PMID: 31211172 Free PMC article.
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