Nishitani H - Search Results

1

CRL4^Cdt2 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA.

Mazian MA, Yamanishi K, Rahman MZA, Ganasen M, Nishitani H. Mazian MA, et al. Among authors: nishitani h. Genes (Basel). 2022 Jan 29;13(2):266. doi: 10.3390/genes13020266. Genes (Basel). 2022. PMID: 35205311 Free PMC article. Review.

2

A DNA-binding domain in the C-terminal region of Cdt2 enhances the DNA synthesis-coupled CRL4Cdt2 ubiquitin ligase activity for Cdt1.

Mazian MA, Suenaga N, Ishii T, Hayashi A, Shiomi Y, Nishitani H. Mazian MA, et al. Among authors: nishitani h. J Biochem. 2019 Jun 1;165(6):505-516. doi: 10.1093/jb/mvz001. J Biochem. 2019. PMID: 30649446

3

Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4^Cdt2 for PCNA and its ubiquitination activity in S phase.

Nukina K, Hayashi A, Shiomi Y, Sugasawa K, Ohtsubo M, Nishitani H. Nukina K, et al. Among authors: nishitani h. Genes Cells. 2018 Mar;23(3):200-213. doi: 10.1111/gtc.12563. Epub 2018 Feb 9. Genes Cells. 2018. PMID: 29424068 Free article.

4

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis.

Michishita M, Morimoto A, Ishii T, Komori H, Shiomi Y, Higuchi Y, Nishitani H. Michishita M, et al. Among authors: nishitani h. Genes Cells. 2011 Jan;16(1):12-22. doi: 10.1111/j.1365-2443.2010.01464.x. Epub 2010 Dec 9. Genes Cells. 2011. PMID: 21143559 Free article.

5

Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin.

Shiomi Y, Nishitani H. Shiomi Y, et al. Among authors: nishitani h. Genes Cells. 2013 Nov;18(11):946-59. doi: 10.1111/gtc.12087. Epub 2013 Aug 13. Genes Cells. 2013. PMID: 23937667 Free article.

6

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H. Shiomi Y, et al. Among authors: nishitani h. Mol Cell Biol. 2012 Jun;32(12):2279-88. doi: 10.1128/MCB.06506-11. Epub 2012 Apr 9. Mol Cell Biol. 2012. PMID: 22493068 Free PMC article.

7

Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.

Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H. Sakaguchi H, et al. Among authors: nishitani h. PLoS One. 2012;7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28. PLoS One. 2012. PMID: 23029527 Free PMC article.

8

PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells.

Hayashi A, Suenaga N, Shiomi Y, Nishitani H. Hayashi A, et al. Among authors: nishitani h. Methods Mol Biol. 2014;1170:367-82. doi: 10.1007/978-1-4939-0888-2_19. Methods Mol Biol. 2014. PMID: 24906324

9

Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication.

Shiomi Y, Nishitani H. Shiomi Y, et al. Among authors: nishitani h. Genes (Basel). 2017 Jan 26;8(2):52. doi: 10.3390/genes8020052. Genes (Basel). 2017. PMID: 28134787 Free PMC article. Review.

10

CRL4^Cdt2: Coupling Genome Stability to Ubiquitination.

Panagopoulos A, Taraviras S, Nishitani H, Lygerou Z. Panagopoulos A, et al. Among authors: nishitani h. Trends Cell Biol. 2020 Apr;30(4):290-302. doi: 10.1016/j.tcb.2020.01.005. Epub 2020 Feb 7. Trends Cell Biol. 2020. PMID: 32044173 Review.

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