Li Z - Search Results

1

Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study.

Dou X, Sun X, Huang H, Jiang L, Jin Z, Liu Y, Zou Y, Li Z, Zhu G, Jin H, Jiao N, Zhang L, Liu Z, Zhang L. Dou X, et al. Among authors: li z. Eur J Med Chem. 2022 Apr 5;233:114196. doi: 10.1016/j.ejmech.2022.114196. Epub 2022 Feb 23. Eur J Med Chem. 2022. PMID: 35231830

2

Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder.

Li W, Liu J, Fan M, Li Z, Chen Y, Zhang G, Huang Z, Zhang L. Li W, et al. Among authors: li z. Molecules. 2018 Apr 24;23(5):996. doi: 10.3390/molecules23050996. Molecules. 2018. PMID: 29695090 Free PMC article.

3

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket.

Yu P, Liu Z, Yu X, Ye P, Liu H, Xue X, Yang L, Li Z, Wu Y, Fang C, Zhao YJ, Yang F, Luo JH, Jiang LH, Zhang L, Zhang L, Yang W. Yu P, et al. Among authors: li z. Cell Rep. 2019 Jun 18;27(12):3684-3695.e4. doi: 10.1016/j.celrep.2019.05.067. Cell Rep. 2019. PMID: 31216484 Free article.

4

Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF₃) derivatives as potential anticancer agents.

He X, Zhong M, Li S, Li X, Li Y, Li Z, Gao Y, Ding F, Wen D, Lei Y, Zhang Y. He X, et al. Among authors: li s, li y, li z, li x. Eur J Med Chem. 2020 Dec 15;208:112864. doi: 10.1016/j.ejmech.2020.112864. Epub 2020 Sep 20. Eur J Med Chem. 2020. PMID: 32987314 Free article.

5

Discovery of Novel and Potent N-Methyl-d-aspartate Receptor Positive Allosteric Modulators with Antidepressant-like Activity in Rodent Models.

Li Z, Cai G, Fang F, Li W, Fan M, Lian J, Qiu Y, Xu X, Lv X, Li Y, Zheng R, Wang Y, Li Z, Zhang G, Liu Z, Huang Z, Zhang L. Li Z, et al. Among authors: li y, li w. J Med Chem. 2021 May 13;64(9):5551-5576. doi: 10.1021/acs.jmedchem.0c02018. Epub 2021 May 3. J Med Chem. 2021. PMID: 33934604

6

Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.

Wang Y, Hu X, Huang H, Jin Z, Gao J, Guo Y, Zhong Y, Li Z, Zong X, Wang K, Zhang L, Liu Z. Wang Y, et al. Among authors: li z. Eur J Med Chem. 2022 Jul 5;237:114413. doi: 10.1016/j.ejmech.2022.114413. Epub 2022 Apr 26. Eur J Med Chem. 2022. PMID: 35512566

7

The structure-based optimization of 3-substituted indolin-2-one derivatives as potent and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors and biological evaluation.

Li Z, Zhu G, Liu X, Gao T, Fang F, Dou X, Li Y, Zheng R, Jin H, Zhang L, Liu Z, Zhang L. Li Z, et al. Among authors: li y. Eur J Med Chem. 2023 Mar 15;250:115167. doi: 10.1016/j.ejmech.2023.115167. Epub 2023 Feb 3. Eur J Med Chem. 2023. PMID: 36764123

8

Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5.

Pan P, Geng T, Li Z, Ding X, Shi M, Li Y, Wang Y, Shi Y, Wu J, Zhong L, Ji D, Li Z, Meng X. Pan P, et al. Among authors: li y, li z. J Med Chem. 2023 Oct 12;66(19):13568-13586. doi: 10.1021/acs.jmedchem.3c00864. Epub 2023 Sep 26. J Med Chem. 2023. PMID: 37751283

9

Carbazole and tetrahydro-carboline derivatives as dopamine D₃ receptor antagonists with the multiple antipsychotic-like properties.

Li Z, Fang F, Li Y, Lv X, Zheng R, Jiao P, Wang Y, Zhu G, Jin Z, Xu X, Qiu Y, Zhang G, Li Z, Liu Z, Zhang L. Li Z, et al. Among authors: li y. Acta Pharm Sin B. 2023 Nov;13(11):4553-4577. doi: 10.1016/j.apsb.2023.07.024. Epub 2023 Jul 27. Acta Pharm Sin B. 2023. PMID: 37969740 Free PMC article.

10

Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production.

Wang S, Zuo Z, Ouyang Z, Liu X, Wang J, Shan Y, Meng R, Zhao Z, Liu X, Liu X, Jin Y, Li Z, Zhang H, Wang L, Cong Y. Wang S, et al. Among authors: li z. Biochem Biophys Res Commun. 2024 Apr 16;704:149661. doi: 10.1016/j.bbrc.2024.149661. Epub 2024 Feb 15. Biochem Biophys Res Commun. 2024. PMID: 38417343

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