Behshad E - Search Results

1

Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.

Koblish HK, Wu L, Wang LS, Liu PCC, Wynn R, Rios-Doria J, Spitz S, Liu H, Volgina A, Zolotarjova N, Kapilashrami K, Behshad E, Covington M, Yang YO, Li J, Diamond S, Soloviev M, O'Hayer K, Rubin S, Kanellopoulou C, Yang G, Rupar M, DiMatteo D, Lin L, Stevens C, Zhang Y, Thekkat P, Geschwindt R, Marando C, Yeleswaram S, Jackson J, Scherle P, Huber R, Yao W, Hollis G. Koblish HK, et al. Among authors: behshad e. Cancer Discov. 2022 Jun 2;12(6):1482-1499. doi: 10.1158/2159-8290.CD-21-1156. Cancer Discov. 2022. PMID: 35254416 Free PMC article. Clinical Trial.

2

A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.

Liu X, Wang Q, Yang G, Marando C, Koblish HK, Hall LM, Fridman JS, Behshad E, Wynn R, Li Y, Boer J, Diamond S, He C, Xu M, Zhuo J, Yao W, Newton RC, Scherle PA. Liu X, et al. Among authors: behshad e. Clin Cancer Res. 2011 Nov 15;17(22):7127-38. doi: 10.1158/1078-0432.CCR-11-1157. Epub 2011 Sep 14. Clin Cancer Res. 2011. PMID: 21918175

3

The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.

Zhang Q, Zhang Y, Diamond S, Boer J, Harris JJ, Li Y, Rupar M, Behshad E, Gardiner C, Collier P, Liu P, Burn T, Wynn R, Hollis G, Yeleswaram S. Zhang Q, et al. Among authors: behshad e. Drug Metab Dispos. 2014 Oct;42(10):1656-62. doi: 10.1124/dmd.114.058883. Epub 2014 Jul 25. Drug Metab Dispos. 2014. PMID: 25063672

4

Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase.

Behshad E, Klabe RM, Margulis A, Becker-Pasha M, Rupar MJ, Collier P, Liu PC, Hollis GF, Burn TC, Wynn R. Behshad E, et al. Curr Chem Genomics. 2010 Apr 23;4:27-33. doi: 10.2174/1875397301004010027. Curr Chem Genomics. 2010. PMID: 20556206 Free PMC article.

5

Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: formation of the persulfide intermediate.

Behshad E, Bollinger JM Jr. Behshad E, et al. Biochemistry. 2009 Dec 22;48(50):12014-23. doi: 10.1021/bi802161u. Biochemistry. 2009. PMID: 19883076

6

Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductants.

Behshad E, Parkin SE, Bollinger JM Jr. Behshad E, et al. Biochemistry. 2004 Sep 28;43(38):12220-6. doi: 10.1021/bi049143e. Biochemistry. 2004. PMID: 15379560

7

How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy.

Lees NS, Chen D, Walsby CJ, Behshad E, Frey PA, Hoffman BM. Lees NS, et al. Among authors: behshad e. J Am Chem Soc. 2006 Aug 9;128(31):10145-54. doi: 10.1021/ja061282r. J Am Chem Soc. 2006. PMID: 16881644

8

Enantiomeric free radicals and enzymatic control of stereochemistry in a radical mechanism: the case of lysine 2,3-aminomutases.

Behshad E, Ruzicka FJ, Mansoorabadi SO, Chen D, Reed GH, Frey PA. Behshad E, et al. Biochemistry. 2006 Oct 24;45(42):12639-46. doi: 10.1021/bi061328t. Biochemistry. 2006. PMID: 17042480 Free PMC article.

9

A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase.

Berkovitch F, Behshad E, Tang KH, Enns EA, Frey PA, Drennan CL. Berkovitch F, et al. Among authors: behshad e. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15870-5. doi: 10.1073/pnas.0407074101. Epub 2004 Oct 28. Proc Natl Acad Sci U S A. 2004. PMID: 15514022 Free PMC article.

10

Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase.

Maity AN, Hsieh CP, Huang MH, Chen YH, Tang KH, Behshad E, Frey PA, Ke SC. Maity AN, et al. Among authors: behshad e. J Phys Chem B. 2009 Sep 10;113(36):12161-3. doi: 10.1021/jp905357a. J Phys Chem B. 2009. PMID: 19685884

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