Inhibition of GSK-3β induces AP-1-mediated osteopontin expression to promote cholestatic liver fibrosis.
Zhuang S, Hua X, He K, Zhou T, Zhang J, Wu H, Ma X, Xia Q, Zhang J.
Zhuang S, et al. Among authors: he k.
FASEB J. 2018 Aug;32(8):4494-4503. doi: 10.1096/fj.201701137R. Epub 2018 Mar 12.
FASEB J. 2018.
PMID: 29529390
These observations indicate that GSK-3beta inhibition up-regulates OPN expression via AP-1 activation, which accelerates the progression of cholestatic liver fibrosis in patients with CLD and in BDL mice.-Zhuang, S., Hua, X., He, K., Zhou, T., Zhang, J., Wu, H., Ma, …
These observations indicate that GSK-3beta inhibition up-regulates OPN expression via AP-1 activation, which accelerates the progression of …