Siau JW - Search Results

1

A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.

Kaldmäe M, Vosselman T, Zhong X, Lama D, Chen G, Saluri M, Kronqvist N, Siau JW, Ng AS, Ghadessy FJ, Sabatier P, Vojtesek B, Sarr M, Sahin C, Österlund N, Ilag LL, Väänänen VA, Sedimbi S, Arsenian-Henriksson M, Zubarev RA, Nilsson L, Koeck PJB, Rising A, Abelein A, Fritz N, Johansson J, Lane DP, Landreh M. Kaldmäe M, et al. Among authors: siau jw. Structure. 2022 May 5;30(5):733-742.e7. doi: 10.1016/j.str.2022.02.013. Epub 2022 Mar 14. Structure. 2022. PMID: 35290795 Free article.

2

Analysis of p53 binding to DNA by fluorescence imaging microscopy.

Ong HJ, Siau JW, Zhang JB, Hong M, Flotow H, Ghadessy F. Ong HJ, et al. Among authors: siau jw. Micron. 2012 Sep;43(9):996-1000. doi: 10.1016/j.micron.2012.03.024. Epub 2012 Apr 6. Micron. 2012. PMID: 22537717

3

Rapid screening of protein-protein interaction inhibitors using the protease exclusion assay.

Nirantar SR, Li X, Siau JW, Ghadessy FJ. Nirantar SR, et al. Among authors: siau jw. Biosens Bioelectron. 2014 Jun 15;56:250-7. doi: 10.1016/j.bios.2013.12.060. Epub 2014 Jan 17. Biosens Bioelectron. 2014. PMID: 24508816

4

Directed evolution of λ integrase activity and specificity by genetic derepression.

Siau JW, Chee S, Makhija H, Wai CM, Chandra SH, Peter S, Dröge P, Ghadessy FJ. Siau JW, et al. Protein Eng Des Sel. 2015 Jul;28(7):211-20. doi: 10.1093/protein/gzv015. Epub 2015 Mar 18. Protein Eng Des Sel. 2015. PMID: 25787692

5

The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans.

Coffill CR, Lee AP, Siau JW, Chee SM, Joseph TL, Tan YS, Madhumalar A, Tay BH, Brenner S, Verma CS, Ghadessy FJ, Venkatesh B, Lane DP. Coffill CR, et al. Among authors: siau jw. Genes Dev. 2016 Feb 1;30(3):281-92. doi: 10.1101/gad.274118.115. Epub 2016 Jan 21. Genes Dev. 2016. PMID: 26798135 Free PMC article.

6

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens.

Siau JW, Coffill CR, Zhang WV, Tan YS, Hundt J, Lane D, Verma C, Ghadessy F. Siau JW, et al. Sci Rep. 2016 Sep 28;6:33972. doi: 10.1038/srep33972. Sci Rep. 2016. PMID: 27678309 Free PMC article.

7

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

Chee SMQ, Wongsantichon J, Siau J, Thean D, Ferrer F, Robinson RC, Lane DP, Brown CJ, Ghadessy FJ. Chee SMQ, et al. PLoS One. 2017 Dec 11;12(12):e0189379. doi: 10.1371/journal.pone.0189379. eCollection 2017. PLoS One. 2017. PMID: 29228061 Free PMC article.

8

Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function.

Lau SY, Siau JW, Sobota RM, Wang CI, Zhong P, Lane DP, Ghadessy FJ. Lau SY, et al. Among authors: siau jw. Protein Eng Des Sel. 2018 Jul 1;31(7-8):301-312. doi: 10.1093/protein/gzy018. Protein Eng Des Sel. 2018. PMID: 30169723 Free PMC article.

9

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Pradhan MR, Siau JW, Kannan S, Nguyen MN, Ouaray Z, Kwoh CK, Lane DP, Ghadessy F, Verma CS. Pradhan MR, et al. Among authors: siau jw. Nucleic Acids Res. 2019 Feb 28;47(4):1637-1652. doi: 10.1093/nar/gky1314. Nucleic Acids Res. 2019. PMID: 30649466 Free PMC article.

10

Directed co-evolution of interacting protein-peptide pairs by compartmentalized two-hybrid replication (C2HR).

Siau JW, Nonis S, Chee S, Koh LQ, Ferrer FJ, Brown CJ, Ghadessy FJ. Siau JW, et al. Nucleic Acids Res. 2020 Dec 16;48(22):e128. doi: 10.1093/nar/gkaa933. Nucleic Acids Res. 2020. PMID: 33104786 Free PMC article.

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