Gilbert IH - Search Results

1

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Smith A, Wall RJ, Patterson S, Rowan T, Rico Vidal E, Stojanovski L, Huggett M, Hampton SE, Thomas MG, Corpas Lopez V, Gillingwater K, Duke J, Napier G, Peter R, Vitouley HS, Harrison JR, Milne R, Jeacock L, Baker N, Davis SH, Simeons F, Riley J, Horn D, Brun R, Zuccotto F, Witty MJ, Wyllie S, Read KD, Gilbert IH. Smith A, et al. Among authors: gilbert ih. J Med Chem. 2022 Apr 14;65(7):5606-5624. doi: 10.1021/acs.jmedchem.1c02104. Epub 2022 Mar 18. J Med Chem. 2022. PMID: 35303411 Free PMC article.

2

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Zuccotto F, Brun R, Gonzalez Pacanowska D, Ruiz Perez LM, Gilbert IH. Zuccotto F, et al. Among authors: gilbert ih. Bioorg Med Chem Lett. 1999 May 17;9(10):1463-8. doi: 10.1016/s0960-894x(99)00213-9. Bioorg Med Chem Lett. 1999. PMID: 10360757

3

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.

Siddiqui AQ, McGuigan C, Ballatore C, Zuccotto F, Gilbert IH, De Clercq E, Balzarini J. Siddiqui AQ, et al. Among authors: gilbert ih. J Med Chem. 1999 Oct 7;42(20):4122-8. doi: 10.1021/jm9807104. J Med Chem. 1999. PMID: 10514282

4

Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

Chowdhury SF, Villamor VB, Guerrero RH, Leal I, Brun R, Croft SL, Goodman JM, Maes L, Ruiz-Perez LM, Pacanowska DG, Gilbert IH. Chowdhury SF, et al. Among authors: gilbert ih. J Med Chem. 1999 Oct 21;42(21):4300-12. doi: 10.1021/jm981130+. J Med Chem. 1999. PMID: 10543874

5

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Zuccotto F, Zvelebil M, Brun R, Chowdhury SF, Di Lucrezia R, Leal I, Maes L, Ruiz-Perez LM, Gonzalez Pacanowska D, Gilbert IH. Zuccotto F, et al. Among authors: gilbert ih. Eur J Med Chem. 2001 May;36(5):395-405. doi: 10.1016/s0223-5234(01)01235-1. Eur J Med Chem. 2001. PMID: 11451529

6

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

Klenke B, Stewart M, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: gilbert ih. J Med Chem. 2001 Oct 11;44(21):3440-52. doi: 10.1021/jm010854+. J Med Chem. 2001. PMID: 11585449

7

Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase.

Chowdhury SF, Guerrero RH, Brun R, Ruiz-Perez LM, Pacanowska DG, Gilbert IH. Chowdhury SF, et al. Among authors: gilbert ih. J Enzyme Inhib Med Chem. 2002 Oct;17(5):293-302. doi: 10.1080/1475636021000059083. J Enzyme Inhib Med Chem. 2002. PMID: 12683746 Free article.

8

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.

Dardonville C, Rinaldi E, Hanau S, Barrett MP, Brun R, Gilbert IH. Dardonville C, et al. Among authors: gilbert ih. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. doi: 10.1016/s0968-0896(03)00191-3. Bioorg Med Chem. 2003. PMID: 12818683

9

Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.

Klenke B, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: gilbert ih. J Antimicrob Chemother. 2003 Aug;52(2):290-3. doi: 10.1093/jac/dkg307. Epub 2003 Jul 1. J Antimicrob Chemother. 2003. PMID: 12837742

10

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.

Pez D, Leal I, Zuccotto F, Boussard C, Brun R, Croft SL, Yardley V, Ruiz Perez LM, Gonzalez Pacanowska D, Gilbert IH. Pez D, et al. Among authors: gilbert ih. Bioorg Med Chem. 2003 Nov 3;11(22):4693-711. doi: 10.1016/j.bmc.2003.08.012. Bioorg Med Chem. 2003. PMID: 14556785

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