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NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, Krizova A, Kirpalani A, Gregorieff A, Ni R, Chan K, Gill MK, Attisano L, Wrana JL, Yuen DA. Zhang T, et al. Among authors: mcevoy cm. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028. doi: 10.1126/scitranslmed.aaz4028. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320001
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis.
He X, Tolosa MF, Zhang T, Goru SK, Ulloa Severino L, Misra PS, McEvoy CM, Caldwell L, Szeto SG, Gao F, Chen X, Atin C, Ki V, Vukosa N, Hu C, Zhang J, Yip C, Krizova A, Wrana JL, Yuen DA. He X, et al. Among authors: mcevoy cm. JCI Insight. 2022 Feb 22;7(4):e146243. doi: 10.1172/jci.insight.146243. JCI Insight. 2022. PMID: 35191398 Free PMC article.
Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease.
Clotet-Freixas S, Zaslaver O, Kotlyar M, Pastrello C, Quaile AT, McEvoy CM, Saha AD, Farkona S, Boshart A, Zorcic K, Neupane S, Manion K, Allen M, Chan M, Chen X, Arnold AP, Sekula P, Steinbrenner I, Köttgen A, Dart AB, Wicklow B, McGavock JM, Blydt-Hansen TD, Barrios C, Riera M, Soler MJ, Isenbrandt A, Lamontagne-Proulx J, Pradeloux S, Coulombe K, Soulet D, Rajasekar S, Zhang B, John R, Mehrotra A, Gehring A, Puhka M, Jurisica I, Woo M, Scholey JW, Röst H, Konvalinka A. Clotet-Freixas S, et al. Among authors: mcevoy cm. Sci Transl Med. 2024 Mar 6;16(737):eabm2090. doi: 10.1126/scitranslmed.abm2090. Epub 2024 Mar 6. Sci Transl Med. 2024. PMID: 38446901
Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.
Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C; GENIE Consortium. Brennan EP, et al. Among authors: mcevoy cm. J Am Soc Nephrol. 2013 Mar;24(4):627-37. doi: 10.1681/ASN.2012060550. Epub 2013 Mar 21. J Am Soc Nephrol. 2013. PMID: 23520204 Free PMC article.
The genetics of diabetic nephropathy.
Brennan E, McEvoy C, Sadlier D, Godson C, Martin F. Brennan E, et al. Genes (Basel). 2013 Nov 5;4(4):596-619. doi: 10.3390/genes4040596. Genes (Basel). 2013. PMID: 24705265 Free PMC article.
NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells.
McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D. McEvoy C, et al. Front Immunol. 2017 Jan 23;8:7. doi: 10.3389/fimmu.2017.00007. eCollection 2017. Front Immunol. 2017. PMID: 28167941 Free PMC article.
20 results