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Page 1
Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models.
Cohen AA, van Doremalen N, Greaney AJ, Andersen H, Sharma A, Starr TN, Keeffe JR, Fan C, Schulz JE, Gnanapragasam PNP, Kakutani LM, West AP Jr, Saturday G, Lee YE, Gao H, Jette CA, Lewis MG, Tan TK, Townsend AR, Bloom JD, Munster VJ, Bjorkman PJ. Cohen AA, et al. Among authors: townsend ar. bioRxiv [Preprint]. 2022 Mar 28:2022.03.25.485875. doi: 10.1101/2022.03.25.485875. bioRxiv. 2022. Update in: Science. 2022 Aug 5;377(6606):eabq0839. doi: 10.1126/science.abq0839 PMID: 35378752 Free PMC article. Updated. Preprint.
Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals.
Jeewandara C, Aberathna IS, Gomes L, Pushpakumara PD, Danasekara S, Guruge D, Ranasinghe T, Gunasekera B, Kamaladasa A, Kuruppu H, Somathilake G, Dissanayake O, Gamalath N, Ekanayake D, Jayamali J, Jayathilaka D, Mudunkotuwa A, Harvie M, Nimasha T, Wijayamuni R, Schimanski L, Rijal P, Tan TK, Dong T, Townsend A, Ogg GS, Malavige GN. Jeewandara C, et al. medRxiv [Preprint]. 2021 Oct 27:2021.10.27.21265561. doi: 10.1101/2021.10.27.21265561. medRxiv. 2021. Update in: Immun Inflamm Dis. 2022 Apr;10(4):e592. doi: 10.1002/iid3.592 PMID: 34729569 Free PMC article. Updated. Preprint.
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai W, Huo J, Zhou D, Zahradník J, Supasa P, Liu C, Duyvesteyn HME, Ginn HM, Mentzer AJ, Tuekprakhon A, Nutalai R, Wang B, Dijokaite A, Khan S, Avinoam O, Bahar M, Skelly D, Adele S, Johnson SA, Amini A, Ritter T, Mason C, Dold C, Pan D, Assadi S, Bellass A, Omo-Dare N, Koeckerling D, Flaxman A, Jenkin D, Aley PK, Voysey M, Clemens SAC, Naveca FG, Nascimento V, Nascimento F, Fernandes da Costa C, Resende PC, Pauvolid-Correa A, Siqueira MM, Baillie V, Serafin N, Ditse Z, Da Silva K, Madhi S, Nunes MC, Malik T, Openshaw PJ, Baillie JK, Semple MG, Townsend AR, Huang KA, Tan TK, Carroll MW, Klenerman P, Barnes E, Dunachie SJ, Constantinides B, Webster H, Crook D, Pollard AJ, Lambe T; OPTIC consortium; ISARIC4C consortium; Paterson NG, Williams MA, Hall DR, Fry EE, Mongkolsapaya J, Ren J, Schreiber G, Stuart DI, Screaton GR. Dejnirattisai W, et al. Among authors: townsend ar. bioRxiv [Preprint]. 2021 Dec 22:2021.12.03.471045. doi: 10.1101/2021.12.03.471045. bioRxiv. 2021. Update in: Cell. 2022 Feb 3;185(3):467-484.e15. doi: 10.1016/j.cell.2021.12.046 PMID: 34981049 Free PMC article. Updated. Preprint.
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology.
Hills RA, Kit Tan T, Cohen AA, Keeffe JR, Keeble AH, Gnanapragasam PNP, Storm KN, Hill ML, Liu S, Gilbert-Jaramillo J, Afzal M, Napier A, James WS, Bjorkman PJ, Townsend AR, Howarth M. Hills RA, et al. Among authors: townsend ar. bioRxiv [Preprint]. 2023 Feb 24:2023.02.24.529520. doi: 10.1101/2023.02.24.529520. bioRxiv. 2023. Update in: Nat Nanotechnol. 2024 Aug;19(8):1216-1223. doi: 10.1038/s41565-024-01655-9 PMID: 36865256 Free PMC article. Updated. Preprint.
The molecular reach of antibodies crucially underpins their viral neutralisation capacity.
Huhn A, Nissley D, Wilson DB, Kutuzov MA, Donat R, Tan TK, Zhang Y, Barton MI, Liu C, Dejnirattisai W, Supasa P, Mongkolsapaya J, Townsend A, James W, Screaton G, van der Merwe PA, Deane CM, Isaacson SA, Dushek O. Huhn A, et al. Nat Commun. 2025 Jan 2;16(1):338. doi: 10.1038/s41467-024-54916-5. Nat Commun. 2025. PMID: 39746910 Free PMC article.
The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine.
Chen X, Mohapatra A, Nguyen HTV, Schimanski L, Kit Tan T, Rijal P, Chen CP, Cheng SH, Lee WH, Chou YC, Townsend AR, Ma C, Huang KA. Chen X, et al. Among authors: townsend ar. PLoS Pathog. 2024 Jun 10;20(6):e1012246. doi: 10.1371/journal.ppat.1012246. eCollection 2024 Jun. PLoS Pathog. 2024. PMID: 38857264 Free PMC article.
A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies.
Donnellan FR, Rayaprolu V, Rijal P, O'Dowd V, Parvate A, Callaway H, Hariharan C, Parekh D, Hui S, Shaffer K, Avalos RD, Hastie K, Schimanski L, Müller-Kräuter H, Strecker T, Balaram A, Halfmann P, Saphire EO, Lightwood DJ, Townsend AR, Draper SJ. Donnellan FR, et al. Among authors: townsend ar. bioRxiv [Preprint]. 2024 Jun 25:2024.06.21.600001. doi: 10.1101/2024.06.21.600001. bioRxiv. 2024. PMID: 38979279 Free PMC article. Preprint.
Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses.
Hills RA, Tan TK, Cohen AA, Keeffe JR, Keeble AH, Gnanapragasam PNP, Storm KN, Rorick AV, West AP Jr, Hill ML, Liu S, Gilbert-Jaramillo J, Afzal M, Napier A, Admans G, James WS, Bjorkman PJ, Townsend AR, Howarth MR. Hills RA, et al. Among authors: townsend ar. Nat Nanotechnol. 2024 Aug;19(8):1216-1223. doi: 10.1038/s41565-024-01655-9. Epub 2024 May 6. Nat Nanotechnol. 2024. PMID: 38710880 Free PMC article.
Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V. Barnkob MB, et al. Among authors: townsend ar. Nat Commun. 2024 Apr 24;15(1):3448. doi: 10.1038/s41467-024-47775-7. Nat Commun. 2024. PMID: 38658563 Free PMC article. No abstract available.
Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V. Barnkob MB, et al. Among authors: townsend ar. Nat Commun. 2024 Apr 12;15(1):3173. doi: 10.1038/s41467-024-47424-z. Nat Commun. 2024. PMID: 38609390 Free PMC article.
181 results