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Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Grychowska K, Olejarz-Maciej A, Blicharz K, Pietruś W, Karcz T, Kurczab R, Koczurkiewicz P, Doroz-Płonka A, Latacz G, Keeri AR, Piska K, Satała G, Pęgiel J, Trybała W, Jastrzębska-Więsek M, Bojarski AJ, Lamaty F, Partyka A, Walczak M, Krawczyk M, Malikowska-Racia N, Popik P, Zajdel P. Grychowska K, et al. Eur J Med Chem. 2022 Jun 5;236:114329. doi: 10.1016/j.ejmech.2022.114329. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35397400 Free article.
Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents.
Malinka W, Redzicka A, Jastrzębska-Więsek M, Filipek B, Dybała M, Karczmarzyk Z, Urbańczyk-Lipkowska Z, Kalicki P. Malinka W, et al. Eur J Med Chem. 2011 Oct;46(10):4992-9. doi: 10.1016/j.ejmech.2011.08.006. Epub 2011 Aug 9. Eur J Med Chem. 2011. PMID: 21864951
Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.
Zajdel P, Marciniec K, Maślankiewicz A, Paluchowska MH, Satała G, Partyka A, Jastrzębska-Więsek M, Wróbel D, Wesołowska A, Duszyńska B, Bojarski AJ, Pawłowski M. Zajdel P, et al. Bioorg Med Chem. 2011 Nov 15;19(22):6750-9. doi: 10.1016/j.bmc.2011.09.044. Epub 2011 Sep 29. Bioorg Med Chem. 2011. PMID: 22001327
Anxiolytic-like activity of zinc in rodent tests.
Partyka A, Jastrzębska-Więsek M, Szewczyk B, Stachowicz K, Sławińska A, Poleszak E, Doboszewska U, Pilc A, Nowak G. Partyka A, et al. Pharmacol Rep. 2011;63(4):1050-5. doi: 10.1016/s1734-1140(11)70621-1. Pharmacol Rep. 2011. PMID: 22001993 Free article.
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.
Zajdel P, Marciniec K, Maślankiewicz A, Satała G, Duszyńska B, Bojarski AJ, Partyka A, Jastrzębska-Więsek M, Wróbel D, Wesołowska A, Pawłowski M. Zajdel P, et al. Bioorg Med Chem. 2012 Feb 15;20(4):1545-56. doi: 10.1016/j.bmc.2011.12.039. Epub 2012 Jan 4. Bioorg Med Chem. 2012. PMID: 22277589
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.
Zajdel P, Marciniec K, Maślankiewicz A, Grychowska K, Satała G, Duszyńska B, Lenda T, Siwek A, Nowak G, Partyka A, Wróbel D, Jastrzębska-Więsek M, Bojarski AJ, Wesołowska A, Pawłowski M. Zajdel P, et al. Eur J Med Chem. 2013 Feb;60:42-50. doi: 10.1016/j.ejmech.2012.11.042. Epub 2012 Dec 5. Eur J Med Chem. 2013. PMID: 23279866
New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation.
Chłoń-Rzepa G, Zmudzki P, Satała G, Duszyńska B, Partyka A, Wróbel D, Jastrzębska-Więsek M, Wesołowska A, Bojarski AJ, Pawłowski M, Zajdel P. Chłoń-Rzepa G, et al. Pharmacol Rep. 2013;65(1):15-29. doi: 10.1016/s1734-1140(13)70960-5. Pharmacol Rep. 2013. PMID: 23563020 Free article.
78 results