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Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Grychowska K, Olejarz-Maciej A, Blicharz K, Pietruś W, Karcz T, Kurczab R, Koczurkiewicz P, Doroz-Płonka A, Latacz G, Keeri AR, Piska K, Satała G, Pęgiel J, Trybała W, Jastrzębska-Więsek M, Bojarski AJ, Lamaty F, Partyka A, Walczak M, Krawczyk M, Malikowska-Racia N, Popik P, Zajdel P. Grychowska K, et al. Among authors: piska k. Eur J Med Chem. 2022 Jun 5;236:114329. doi: 10.1016/j.ejmech.2022.114329. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35397400 Free article.
Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities.
Zagórska A, Partyka A, Bucki A, Kołaczkowski M, Jastrzębska-Więsek M, Czopek A, Siwek A, Głuch-Lutwin M, Bednarski M, Bajda M, Jończyk J, Piska K, Koczurkiewicz P, Wesołowska A, Pawłowski M. Zagórska A, et al. Among authors: piska k. Chem Biol Drug Des. 2019 Apr;93(4):511-521. doi: 10.1111/cbdd.13442. Epub 2018 Dec 4. Chem Biol Drug Des. 2019. PMID: 30422400
Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity.
Grychowska K, Chaumont-Dubel S, Kurczab R, Koczurkiewicz P, Deville C, Krawczyk M, Pietruś W, Satała G, Buda S, Piska K, Drop M, Bantreil X, Lamaty F, Pękala E, Bojarski AJ, Popik P, Marin P, Zajdel P. Grychowska K, et al. Among authors: piska k. ACS Chem Neurosci. 2019 Jul 17;10(7):3183-3196. doi: 10.1021/acschemneuro.8b00618. Epub 2019 Apr 2. ACS Chem Neurosci. 2019. PMID: 30896921
38 results