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Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: jewett mc. Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25. Sci Transl Med. 2022. PMID: 35412328 Free PMC article.
De novo design of protein logic gates.
Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. Chen Z, et al. Among authors: jewett mc. Science. 2020 Apr 3;368(6486):78-84. doi: 10.1126/science.aay2790. Science. 2020. PMID: 32241946 Free PMC article.
Cell-free styrene biosynthesis at high titers.
Grubbe WS, Rasor BJ, Krüger A, Jewett MC, Karim AS. Grubbe WS, et al. Among authors: jewett mc. Metab Eng. 2020 Sep;61:89-95. doi: 10.1016/j.ymben.2020.05.009. Epub 2020 Jun 2. Metab Eng. 2020. PMID: 32502620
Cell-Free Exploration of the Natural Product Chemical Space.
Bogart JW, Cabezas MD, Vögeli B, Wong DA, Karim AS, Jewett MC. Bogart JW, et al. Among authors: jewett mc. Chembiochem. 2021 Jan 5;22(1):84-91. doi: 10.1002/cbic.202000452. Epub 2020 Sep 22. Chembiochem. 2021. PMID: 32783358 Free PMC article. Review.
Modular cell-free expression plasmids to accelerate biological design in cells.
Karim AS, Liew FE, Garg S, Vögeli B, Rasor BJ, Gonnot A, Pavan M, Juminaga A, Simpson SD, Köpke M, Jewett MC. Karim AS, et al. Among authors: jewett mc. Synth Biol (Oxf). 2020 Oct 14;5(1):ysaa019. doi: 10.1093/synbio/ysaa019. eCollection 2020. Synth Biol (Oxf). 2020. PMID: 33344777 Free PMC article.
Toward sustainable, cell-free biomanufacturing.
Rasor BJ, Vögeli B, Landwehr GM, Bogart JW, Karim AS, Jewett MC. Rasor BJ, et al. Among authors: jewett mc. Curr Opin Biotechnol. 2021 Jun;69:136-144. doi: 10.1016/j.copbio.2020.12.012. Epub 2021 Jan 13. Curr Opin Biotechnol. 2021. PMID: 33453438 Review.
Multivalent designed proteins protect against SARS-CoV-2 variants of concern.
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger-Gericke A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken S, Ljubetič A, Edman N, Ueda G, Chow C, Addetia A, Panpradist N, Gale M Jr, Freedman BS, Lutz BR, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D. Hunt AC, et al. Among authors: jewett mc. bioRxiv [Preprint]. 2021 Jul 7:2021.07.07.451375. doi: 10.1101/2021.07.07.451375. bioRxiv. 2021. Update in: Sci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252 PMID: 34268509 Free PMC article. Updated. Preprint.
228 results