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Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.
Kidger AM, Saville MK, Rushworth LK, Davidson J, Stellzig J, Ono M, Kuebelsbeck LA, Janssen KP, Holzmann B, Morton JP, Sansom OJ, Caunt CJ, Keyse SM. Kidger AM, et al. Among authors: keyse sm. Oncogene. 2022 May;41(20):2811-2823. doi: 10.1038/s41388-022-02302-0. Epub 2022 Apr 13. Oncogene. 2022. PMID: 35418690 Free PMC article.
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM. Rushworth LK, et al. Among authors: keyse sm. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18267-72. doi: 10.1073/pnas.1420159112. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489104 Free PMC article.
Dual-specificity MAP kinase phosphatases in health and disease.
Seternes OM, Kidger AM, Keyse SM. Seternes OM, et al. Among authors: keyse sm. Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):124-143. doi: 10.1016/j.bbamcr.2018.09.002. Epub 2018 Sep 8. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30401534 Free PMC article. Review.
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF. Reader CS, et al. Among authors: keyse sm. J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30. J Pathol. 2019. PMID: 31259422 Free PMC article.
DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy.
Ferguson BS, Wennersten SA, Demos-Davies KM, Rubino M, Robinson EL, Cavasin MA, Stratton MS, Kidger AM, Hu T, Keyse SM, McKnight RA, Lane RH, Nozik ES, Weiser-Evans MCM, McKinsey TA. Ferguson BS, et al. Among authors: keyse sm. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H382-H389. doi: 10.1152/ajpheart.00115.2021. Epub 2021 Jun 18. Am J Physiol Heart Circ Physiol. 2021. PMID: 34142888 Free PMC article.
83 results