Chen YT - Search Results

1

Discovery of moiety preference by Shapley value in protein kinase family using random forest models.

Huang YW, Hsu YC, Chuang YH, Chen YT, Lin XY, Fan YW, Pathak N, Yang JM. Huang YW, et al. Among authors: chen yt. BMC Bioinformatics. 2022 Apr 15;23(Suppl 4):130. doi: 10.1186/s12859-022-04663-5. BMC Bioinformatics. 2022. PMID: 35428180 Free PMC article.

2

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide.

Lee CC, Chang WH, Chang YS, Yang JM, Chang CS, Hsu KC, Chen YT, Liu TY, Chen YC, Lin SY, Wu YC, Chang JG. Lee CC, et al. Among authors: chen yc, chen yt. Mol Oncol. 2019 Aug;13(8):1744-1762. doi: 10.1002/1878-0261.12524. Epub 2019 Jun 1. Mol Oncol. 2019. PMID: 31152681 Free PMC article.

3

Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing.

Pathak N, Chen YT, Hsu YC, Hsu NY, Kuo CJ, Tsai HP, Kang JJ, Huang CH, Chang SY, Chang YH, Liang PH, Yang JM. Pathak N, et al. Among authors: chen yt. ACS Nano. 2021 Jan 26;15(1):857-872. doi: 10.1021/acsnano.0c07383. Epub 2020 Dec 29. ACS Nano. 2021. PMID: 33373194 Free article.

4

Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors.

Chiou WC, Hsu MS, Chen YT, Yang JM, Tsay YG, Huang HC, Huang C. Chiou WC, et al. Among authors: chen yt. J Enzyme Inhib Med Chem. 2021 Dec;36(1):147-153. doi: 10.1080/14756366.2020.1850710. J Enzyme Inhib Med Chem. 2021. PMID: 33430659 Free PMC article.

5

The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease.

Chiou WC, Chen JC, Chen YT, Yang JM, Hwang LH, Lyu YS, Yang HY, Huang C. Chiou WC, et al. Among authors: chen jc, chen yt. Biochem Biophys Res Commun. 2022 Feb 5;591:130-136. doi: 10.1016/j.bbrc.2020.12.106. Epub 2021 Jan 6. Biochem Biophys Res Commun. 2022. PMID: 33454058 Free PMC article.

6

Pharmacophore anchor models of ATAT1 to discover potential inhibitors and lead optimization.

Hsu NY, Pathak N, Chen YT, Hsu YC, Yang JM. Hsu NY, et al. Among authors: chen yt. Comput Biol Chem. 2021 Aug;93:107513. doi: 10.1016/j.compbiolchem.2021.107513. Epub 2021 May 21. Comput Biol Chem. 2021. PMID: 34052673

7

A novel graph convolutional neural network for predicting interaction sites on protein kinase inhibitors in phosphorylation.

Wang F, Chen YT, Yang JM, Akutsu T. Wang F, et al. Among authors: chen yt. Sci Rep. 2022 Jan 7;12(1):229. doi: 10.1038/s41598-021-04230-7. Sci Rep. 2022. PMID: 34997142 Free PMC article.

8

Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations.

Fan YW, Liu WH, Chen YT, Hsu YC, Pathak N, Huang YW, Yang JM. Fan YW, et al. Among authors: chen yt. BMC Bioinformatics. 2022 Jun 20;23(Suppl 4):242. doi: 10.1186/s12859-022-04760-5. BMC Bioinformatics. 2022. PMID: 35725381 Free PMC article.

9

Identification of pan-kinase-family inhibitors using graph convolutional networks to reveal family-sensitive pre-moieties.

Lin XY, Huang YW, Fan YW, Chen YT, Pathak N, Hsu YC, Yang JM. Lin XY, et al. Among authors: chen yt. BMC Bioinformatics. 2022 Jun 22;23(Suppl 4):247. doi: 10.1186/s12859-022-04773-0. BMC Bioinformatics. 2022. PMID: 35733108 Free PMC article.

10

Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice.

Huang HC, Chen YT, Lin HH, Li ZQ, Yang JM, Tzou SC. Huang HC, et al. Among authors: chen yt. Int J Mol Sci. 2022 Nov 29;23(23):14958. doi: 10.3390/ijms232314958. Int J Mol Sci. 2022. PMID: 36499283 Free PMC article.

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