Brouwer KLR - Search Results

1

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).

Murphy WA, Adiwidjaja J, Sjöstedt N, Yang K, Beaudoin JJ, Spires J, Siler SQ, Neuhoff S, Brouwer KLR. Murphy WA, et al. Among authors: brouwer klr. Clin Pharmacol Ther. 2023 Feb;113(2):275-297. doi: 10.1002/cpt.2614. Epub 2022 Jun 2. Clin Pharmacol Ther. 2023. PMID: 35429164 Free PMC article. Review.

2

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes.

Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL. Turncliff RZ, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):881-9. doi: 10.1124/jpet.106.102616. Epub 2006 May 11. J Pharmacol Exp Ther. 2006. PMID: 16690724 Free article.

3

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL. Lee JK, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):26-34. doi: 10.1124/jpet.109.156653. Epub 2009 Oct 2. J Pharmacol Exp Ther. 2010. PMID: 19801447 Free PMC article.

4

A perspective on efflux transport proteins in the liver.

Köck K, Brouwer KL. Köck K, et al. Clin Pharmacol Ther. 2012 Nov;92(5):599-612. doi: 10.1038/clpt.2012.79. Epub 2012 Sep 5. Clin Pharmacol Ther. 2012. PMID: 22948894 Free PMC article. Review.

5

In vitro methods to support transporter evaluation in drug discovery and development.

Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R; International Transporter Consortium. Brouwer KL, et al. Clin Pharmacol Ther. 2013 Jul;94(1):95-112. doi: 10.1038/clpt.2013.81. Epub 2013 Apr 10. Clin Pharmacol Ther. 2013. PMID: 23588315 Free article. Review.

6

An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters.

Yang K, Köck K, Sedykh A, Tropsha A, Brouwer KL. Yang K, et al. J Pharm Sci. 2013 Sep;102(9):3037-57. doi: 10.1002/jps.23584. Epub 2013 May 7. J Pharm Sci. 2013. PMID: 23653385 Free PMC article. Review.

7

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes.

Pfeifer ND, Yang K, Brouwer KL. Pfeifer ND, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):727-36. doi: 10.1124/jpet.113.207472. Epub 2013 Sep 10. J Pharmacol Exp Ther. 2013. PMID: 24023367 Free PMC article.

8

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL. Köck K, et al. Drug Metab Dispos. 2014 Apr;42(4):665-74. doi: 10.1124/dmd.113.054304. Epub 2013 Oct 23. Drug Metab Dispos. 2014. PMID: 24154606 Free PMC article.

9

An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.

Yang K, Pfeifer ND, Hardwick RN, Yue W, Stewart PW, Brouwer KL. Yang K, et al. Mol Pharm. 2014 Mar 3;11(3):766-75. doi: 10.1021/mp400471e. Epub 2014 Jan 30. Mol Pharm. 2014. PMID: 24410402 Free PMC article.

10

Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.

Yang K, Brouwer KL. Yang K, et al. Drug Metab Dispos. 2014 Jul;42(7):1219-26. doi: 10.1124/dmd.114.057190. Epub 2014 May 5. Drug Metab Dispos. 2014. PMID: 24799397 Free PMC article.

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