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Page 1
A dominant function of LynB kinase in preventing autoimmunity.
Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. Brian BF 4th, et al. Among authors: moriarity bs. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. Sci Adv. 2022. PMID: 35452291 Free PMC article.
Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing.
Wang M, Krueger JB, Gilkey AK, Stelljes EM, Kluesner MG, Pomeroy EJ, Skeate JG, Slipek NJ, Lahr WS, Vázquez PNC, Zhao Y, Eaton EJ, Laoharawee K, Webber BR, Moriarity BS. Wang M, et al. Among authors: moriarity bs. bioRxiv [Preprint]. 2024 Mar 8:2024.03.05.582637. doi: 10.1101/2024.03.05.582637. bioRxiv. 2024. PMID: 38496503 Free PMC article. Preprint.
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.
Dahlvang JD, Dick JK, Sangala JA, Kennedy PR, Pomeroy EJ, Snyder KM, Moushon JM, Thefaine CE, Wu J, Hamilton SE, Felices M, Miller JS, Walcheck B, Webber BR, Moriarity BS, Hart GT. Dahlvang JD, et al. Among authors: moriarity bs. J Immunol. 2023 Apr 15;210(8):1108-1122. doi: 10.4049/jimmunol.2200488. J Immunol. 2023. PMID: 36881874 Free PMC article.
A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy.
Pomeroy EJ, Hunzeker JT, Kluesner MG, Lahr WS, Smeester BA, Crosby MR, Lonetree CL, Yamamoto K, Bendzick L, Miller JS, Geller MA, Walcheck B, Felices M, Webber BR, Starr TK, Moriarity BS. Pomeroy EJ, et al. Among authors: moriarity bs. Mol Ther. 2020 Jan 8;28(1):52-63. doi: 10.1016/j.ymthe.2019.10.009. Epub 2019 Oct 15. Mol Ther. 2020. PMID: 31704085 Free PMC article.
Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV.
Naeimi Kararoudi M, Likhite S, Elmas E, Yamamoto K, Schwartz M, Sorathia K, de Souza Fernandes Pereira M, Sezgin Y, Devine RD, Lyberger JM, Behbehani GK, Chakravarti N, Moriarity BS, Meyer K, Lee DA. Naeimi Kararoudi M, et al. Among authors: moriarity bs. Cell Rep Methods. 2022 Jun 13;2(6):100236. doi: 10.1016/j.crmeth.2022.100236. eCollection 2022 Jun 20. Cell Rep Methods. 2022. PMID: 35784645 Free PMC article.
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade.
Palmer DC, Webber BR, Patel Y, Johnson MJ, Kariya CM, Lahr WS, Parkhurst MR, Gartner JJ, Prickett TD, Lowery FJ, Kishton RJ, Gurusamy D, Franco Z, Vodnala SK, Diers MD, Wolf NK, Slipek NJ, McKenna DH, Sumstad D, Viney L, Henley T, Bürckstümmer T, Baker O, Hu Y, Yan C, Meerzaman D, Padhan K, Lo W, Malekzadeh P, Jia L, Deniger DC, Patel SJ, Robbins PF, McIvor RS, Choudhry M, Rosenberg SA, Moriarity BS, Restifo NP. Palmer DC, et al. Among authors: moriarity bs. Med. 2022 Oct 14;3(10):682-704.e8. doi: 10.1016/j.medj.2022.07.008. Epub 2022 Aug 24. Med. 2022. PMID: 36007524 Free PMC article.
CRISPR-Cas9 base editors and their current role in human therapeutics.
Lahr WS, Sipe CJ, Skeate JG, Webber BR, Moriarity BS. Lahr WS, et al. Among authors: moriarity bs. Cytotherapy. 2023 Mar;25(3):270-276. doi: 10.1016/j.jcyt.2022.11.013. Epub 2023 Jan 10. Cytotherapy. 2023. PMID: 36635153 Free PMC article. Review.
93 results