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Page 1
Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers.
Evrard C, Messina S, Sefrioui D, Frouin É, Auriault ML, Chautard R, Zaanan A, Jaffrelot M, De La Fouchardière C, Aparicio T, Coriat R, Godet J, Silvain C, Randrian V, Sabourin JC, Guimbaud R, Miquelestorena-Standley E, Lecomte T, Moulin V, Karayan-Tapon L, Tachon G, Tougeron D. Evrard C, et al. Among authors: jaffrelot m. Int J Mol Sci. 2022 Apr 17;23(8):4427. doi: 10.3390/ijms23084427. Int J Mol Sci. 2022. PMID: 35457245 Free PMC article.
An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.
Jaffrelot M, Farés N, Brunac AC, Laurenty AP, Danjoux M, Grand D, Icher S, Meilleroux J, Mery E, Buscail E, Maulat C, Toulas C, Vande Perre P, Chipoulet E, Bonnet D, Staub A, Guimbaud R, Selves J. Jaffrelot M, et al. Mod Pathol. 2022 Mar;35(3):427-437. doi: 10.1038/s41379-021-00918-3. Epub 2021 Sep 20. Mod Pathol. 2022. PMID: 34545179 Free PMC article.
FOLFIRI plus BEvacizumab or aFLIbercept after FOLFOX-bevacizumab failure for COlorectal cancer (BEFLICO): An AGEO multicenter study.
Torregrosa C, Pernot S, Vaflard P, Perret A, Tournigand C, Randrian V, Doat S, Neuzillet C, Moulin V, Stouvenot M, Roth G, Darbas T, Auberger B, Godet T, Jaffrelot M, Lambert A, Dubreuil O, Gluszak C, Bernard-Tessier A, Turpin A, Palmieri LJ, Bouche O, Goujon G, Lecomte T, Sefrioui D, Locher C, Grados L, Gignoux P, Trager S, Nassif E, Saint A, Hammel P, Lecaille C, Bureau M, Perrier M, Botsen D, Bourgeois V, Taieb J, Auclin E. Torregrosa C, et al. Among authors: jaffrelot m. Int J Cancer. 2022 Dec 1;151(11):1978-1988. doi: 10.1002/ijc.34166. Epub 2022 Jul 14. Int J Cancer. 2022. PMID: 35833561
CINSARC signature outperforms gold-standard TNM staging and consensus molecular subtypes for clinical outcome in stage II-III colorectal carcinoma.
Brunac AC, Fourquet J, Perot G, Jaffrelot M, Meilleroux J, Danjoux M, Filleron T, Nicolaï V, Guimbaud R, Icher S, Farés N, Selves J, Chibon F. Brunac AC, et al. Among authors: jaffrelot m. Mod Pathol. 2022 Dec;35(12):2002-2010. doi: 10.1038/s41379-022-01166-9. Epub 2022 Oct 6. Mod Pathol. 2022. PMID: 36202996 Free article.
Efficacy of immunotherapy in mismatch repair-deficient advanced colorectal cancer in routine clinical practice. An AGEO study.
Alouani E, Mercier M, Flecchia C, Auclin E, Hollebecque A, Mazard T, Turpin A, Pernot S, Cohen R, Dutherage M, Kim S, Sclafani F, Ben-Abdelghani M, Herve C, Aparicio T, De La Fouchardière C, Perkins G, Hautefeuille V, Jaffrelot M, Gallois C, Bongard V, Tougeron D, Taïeb J, Guimbaud R. Alouani E, et al. Among authors: jaffrelot m. ESMO Open. 2023 Jun;8(3):101574. doi: 10.1016/j.esmoop.2023.101574. Epub 2023 May 25. ESMO Open. 2023. PMID: 37244250 Free PMC article.
The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity.
Labrousse G, Vande Perre P, Parra G, Jaffrelot M, Leroy L, Chibon F, Escudie F, Selves J, Hoffmann JS, Guimbaud R, Lutzmann M. Labrousse G, et al. Among authors: jaffrelot m. NAR Cancer. 2023 Mar 11;5(2):zcad011. doi: 10.1093/narcan/zcad011. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 36915289 Free PMC article.
Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre study.
Nicolle R, Canivet C, Palazzo L, Napoléon B, Ayadi M, Pignolet C, Cros J, Gourgou S, Selves J, Torrisani J, Dusetti N, Cordelier P, Buscail L, Bournet B; BACAP Consortium. Nicolle R, et al. EBioMedicine. 2024 Nov;109:105373. doi: 10.1016/j.ebiom.2024.105373. Epub 2024 Oct 8. EBioMedicine. 2024. PMID: 39383608 Free PMC article.
Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy.
Poumeaud F, Valentin T, Fares N, Segier B, Watson S, Verret B, Tlemsani C, Penel N, Lejeune S, Firmin N, Sabouret A, Thery JC, Bonvalot S, Cottereau E, Cauchin E, Lancon A, Nambot S, Zattara H, Coudert M, Fourme E, Nogues C, Tougeron D, Prieur F, Collonge-Rame MA, Denis C, Laurent-Puig P, Chieze-Valero S, Dreyfus H, Jaffrelot M, Vande Perre P, Rochaix P, Gomez-Mascard A, Rochefort P, Campoy S, Chibon F, Lasset C, Selves J, Guimbaud R. Poumeaud F, et al. Among authors: jaffrelot m. Eur J Cancer. 2024 Dec 21;216:115196. doi: 10.1016/j.ejca.2024.115196. Online ahead of print. Eur J Cancer. 2024. PMID: 39742560
45 results