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Lunasin attenuates oxidant-induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE-/- mice by up-regulating heme oxygenase-1 via PI3K/Akt/Nrf2/ARE pathway.
Gu L, Ye P, Li H, Wang Y, Xu Y, Tian Q, Lei G, Zhao C, Gao Z, Zhao W, Tan S. Gu L, et al. Among authors: zhao w, zhao c. FASEB J. 2019 Apr;33(4):4836-4850. doi: 10.1096/fj.201802251R. Epub 2019 Jan 2. FASEB J. 2019. PMID: 30601695
Our data indicated that lunasin attenuated H(2)O(2)-induced, mitochondria-dependent endothelial apoptosis via down-regulating Bax and up-regulating Bcl-2, inhibiting the mitochondrial depolarization, and reducing the release of cytochrome c, as well as decreasing the activ …
Our data indicated that lunasin attenuated H(2)O(2)-induced, mitochondria-dependent endothelial apoptosis via down-regulating Bax and up-reg …
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