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First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
Guijarro MV, Kellish PC, Dib PE, Paciaroni NG, Nawab A, Andring J, Kulemina L, Borrero NV, Modenutti C, Feely M, Nasri E, Seifert RP, Luo X, Bennett RL, Shabashvili D, Licht JD, McKenna R, Roitberg A, Huigens RW 3rd, Kaye FJ, Zajac-Kaye M. Guijarro MV, et al. Among authors: huigens rw 3rd. JCI Insight. 2023 Apr 25;8(10):e158798. doi: 10.1172/jci.insight.158798. JCI Insight. 2023. PMID: 37097751 Free PMC article.
Molecular characterization of myotonic dystrophy fibroblast cell lines for use in small molecule screening.
Jenquin JR, O'Brien AP, Poukalov K, Lu Y, Frias JA, Shorrock HK, Richardson JI, Mazdiyasni H, Yang H, Huigens RW 3rd, Boykin D, Ranum LPW, Cleary JD, Wang ET, Berglund JA. Jenquin JR, et al. Among authors: huigens rw 3rd. iScience. 2022 Apr 4;25(5):104198. doi: 10.1016/j.isci.2022.104198. eCollection 2022 May 20. iScience. 2022. PMID: 35479399 Free PMC article.
Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Staphylococcus aureus Biofilms.
Liu K, Brivio M, Xiao T, Norwood VM 4th, Kim YS, Jin S, Papagni A, Vaghi L, Huigens RW 3rd. Liu K, et al. Among authors: huigens rw 3rd. ACS Infect Dis. 2022 Feb 11;8(2):280-295. doi: 10.1021/acsinfecdis.1c00402. Epub 2022 Jan 28. ACS Infect Dis. 2022. PMID: 35089005 Free PMC article.
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, Huigens RW 3rd. Yang H, et al. Among authors: huigens rw 3rd. J Med Chem. 2021 Jun 10;64(11):7275-7295. doi: 10.1021/acs.jmedchem.1c00168. Epub 2021 Apr 21. J Med Chem. 2021. PMID: 33881312 Free PMC article.
50 results