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Page 1
Posttranslational modification of microtubules by the MATCAP detyrosinase.
Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR. Landskron L, et al. Among authors: moutin mj. Science. 2022 May 20;376(6595):eabn6020. doi: 10.1126/science.abn6020. Epub 2022 May 20. Science. 2022. PMID: 35482892
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.
Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ. Aillaud C, et al. Among authors: moutin mj. Science. 2017 Dec 15;358(6369):1448-1453. doi: 10.1126/science.aao4165. Epub 2017 Nov 16. Science. 2017. PMID: 29146868
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A. Peris L, et al. Among authors: moutin mj. Brain. 2022 Jul 29;145(7):2486-2506. doi: 10.1093/brain/awab436. Brain. 2022. PMID: 35148384 Free PMC article.
VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules.
Ramirez-Rios S, Choi SR, Sanyal C, Blum TB, Bosc C, Krichen F, Denarier E, Soleilhac JM, Blot B, Janke C, Stoppin-Mellet V, Magiera MM, Arnal I, Steinmetz MO, Moutin MJ. Ramirez-Rios S, et al. Among authors: moutin mj. J Cell Biol. 2023 Feb 6;222(2):e202205096. doi: 10.1083/jcb.202205096. Epub 2022 Dec 13. J Cell Biol. 2023. PMID: 36512346 Free PMC article.
Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, Bao H, Krichen F, Chen L, Andrieux A, Olieric V, Moutin MJ, Steinmetz MO, Huang H. Wang N, et al. Among authors: moutin mj. Nat Struct Mol Biol. 2019 Jul;26(7):571-582. doi: 10.1038/s41594-019-0241-y. Epub 2019 Jun 24. Nat Struct Mol Biol. 2019. PMID: 31235911
Evidence for new C-terminally truncated variants of α- and β-tubulins.
Aillaud C, Bosc C, Saoudi Y, Denarier E, Peris L, Sago L, Taulet N, Cieren A, Tort O, Magiera MM, Janke C, Redeker V, Andrieux A, Moutin MJ. Aillaud C, et al. Among authors: moutin mj. Mol Biol Cell. 2016 Feb 15;27(4):640-53. doi: 10.1091/mbc.E15-03-0137. Epub 2016 Jan 6. Mol Biol Cell. 2016. PMID: 26739754 Free PMC article.
Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice.
Pagnamenta AT, Heemeryck P, Martin HC, Bosc C, Peris L, Uszynski I, Gory-Fauré S, Couly S, Deshpande C, Siddiqui A, Elmonairy AA; WGS500 Consortium; Genomics England Research Consortium; Jayawant S, Murthy S, Walker I, Loong L, Bauer P, Vossier F, Denarier E, Maurice T, Barbier EL, Deloulme JC, Taylor JC, Blair EM, Andrieux A, Moutin MJ. Pagnamenta AT, et al. Among authors: moutin mj. Hum Mol Genet. 2019 Oct 15;28(20):3391-3405. doi: 10.1093/hmg/ddz186. Hum Mol Genet. 2019. PMID: 31363758 Free PMC article.
49 results