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Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity.
Frick L, Hinterland L, Renner K, Vogl M, Babl N, Heckscher S, Weigert A, Weiß S, Gläsner J, Berger R, Oefner PJ, Dettmer K, Kreutz M, Schatz V, Jantsch J. Frick L, et al. Among authors: berger r. Front Immunol. 2022 Apr 14;13:789366. doi: 10.3389/fimmu.2022.789366. eCollection 2022. Front Immunol. 2022. PMID: 35493523 Free PMC article.
D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization.
Böttcher M, Renner K, Berger R, Mentz K, Thomas S, Cardenas-Conejo ZE, Dettmer K, Oefner PJ, Mackensen A, Kreutz M, Mougiakakos D. Böttcher M, et al. Among authors: berger r. Oncoimmunology. 2018 Mar 26;7(7):e1445454. doi: 10.1080/2162402X.2018.1445454. eCollection 2018. Oncoimmunology. 2018. PMID: 29900057 Free PMC article.
Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo.
Siska PJ, Jiao J, Matos C, Singer K, Berger RS, Dettmer K, Oefner PJ, Cully MD, Wang Z, QuinnIII WJ, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH. Siska PJ, et al. Among authors: berger rs. EBioMedicine. 2021 Dec;74:103734. doi: 10.1016/j.ebiom.2021.103734. Epub 2021 Dec 4. EBioMedicine. 2021. PMID: 34875457 Free PMC article.
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R. Kohl L, et al. Among authors: berger r. EMBO Mol Med. 2023 Feb 8;15(2):e15931. doi: 10.15252/emmm.202215931. Epub 2022 Dec 7. EMBO Mol Med. 2023. PMID: 36479617 Free PMC article.
4,058 results