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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Calleja DJ, Kuchel N, Lu BGC, Birkinshaw RW, Klemm T, Doerflinger M, Cooney JP, Mackiewicz L, Au AE, Yap YQ, Blackmore TR, Katneni K, Crighton E, Newman J, Jarman KE, Call MJ, Lechtenberg BC, Czabotar PE, Pellegrini M, Charman SA, Lowes KN, Mitchell JP, Nachbur U, Lessene G, Komander D. Calleja DJ, et al. Among authors: mitchell jp. Front Chem. 2022 Apr 12;10:861209. doi: 10.3389/fchem.2022.861209. eCollection 2022. Front Chem. 2022. PMID: 35494659 Free PMC article.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: mitchell jp. EMBO J. 2020 Sep 15;39(18):e106275. doi: 10.15252/embj.2020106275. Epub 2020 Aug 26. EMBO J. 2020. PMID: 32845033 Free PMC article.
Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS).
Mitchell JP, Carter I, Christopher JD, Copley M, Doub WH, Goodey A, Gruenloh CJ, Larson BB, Lyapustina S, Patel RB, Stein SW, Suman JD. Mitchell JP, et al. AAPS PharmSciTech. 2023 Mar 3;24(3):73. doi: 10.1208/s12249-023-02528-5. AAPS PharmSciTech. 2023. PMID: 36869256 Review.
Moving Forward from "Fine Particle Fraction: The Good and the Bad".
Mitchell JP, Doub W, Christopher JD, Gruenloh CJ, Patel RB, Copley M, Tignor S, Stein SW, Lyapustina S, Newman SP. Mitchell JP, et al. J Aerosol Med Pulm Drug Deliv. 2022 Aug;35(4):225-226. doi: 10.1089/jamp.2022.0017. Epub 2022 May 4. J Aerosol Med Pulm Drug Deliv. 2022. PMID: 35508023 No abstract available.
288 results