Carvalho LAR - Search Results

1

The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.

Carvalho LAR, Bernardes GJL. Carvalho LAR, et al. ChemMedChem. 2022 Jul 19;17(14):e202200174. doi: 10.1002/cmdc.202200174. Epub 2022 May 19. ChemMedChem. 2022. PMID: 35506504 Free PMC article. Review.

2

Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.

Sousa BB, de Almeida CR, Barahona AF, Lopes R, Martins-Logrado A, Cavaco M, Neves V, Carvalho LAR, Labão-Almeida C, Coelho AR, Leal Bento M, Lopes RMRM, Oliveira BL, Castanho MARB, Neumeister P, Deutsch A, Vladimer GI, Krall N, João C, Corzana F, Seixas JD, Fior R, Bernardes GJL. Sousa BB, et al. Among authors: carvalho lar. ACS Pharmacol Transl Sci. 2022 Nov 2;5(11):1156-1168. doi: 10.1021/acsptsci.2c00163. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407952 Free PMC article.

3

Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.

Carvalho LAR, Sousa BB, Zaidman D, Kiely-Collins H, Bernardes GJL. Carvalho LAR, et al. Chembiochem. 2024 Feb 16;25(4):e202300736. doi: 10.1002/cbic.202300736. Epub 2024 Jan 9. Chembiochem. 2024. PMID: 38195841

4

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling.

Carvalho LAR, Almeida VT, Brito JA, Lum KM, Oliveira TF, Guedes RC, Gonçalves LM, Lucas SD, Cravatt BF, Archer M, Moreira R. Carvalho LAR, et al. ACS Chem Biol. 2020 Apr 17;15(4):878-883. doi: 10.1021/acschembio.0c00090. Epub 2020 Mar 20. ACS Chem Biol. 2020. PMID: 32176480

5

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.

Ruivo EF, Gonçalves LM, Carvalho LA, Guedes RC, Hofbauer S, Brito JA, Archer M, Moreira R, Lucas SD. Ruivo EF, et al. ChemMedChem. 2016 Sep 20;11(18):2037-42. doi: 10.1002/cmdc.201600258. Epub 2016 Jul 28. ChemMedChem. 2016. PMID: 27465595

6

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons.

Barbosa M, Gomes C, Sequeira C, Gonçalves-Ribeiro J, Pina CC, Carvalho LA, Moreira R, Vaz SH, Vaz AR, Brites D. Barbosa M, et al. Front Cell Dev Biol. 2021 Apr 23;9:634355. doi: 10.3389/fcell.2021.634355. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33968923 Free PMC article.

7

Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.

Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. Carvalho LAR, et al. Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202210498. doi: 10.1002/anie.202210498. Epub 2022 Oct 28. Angew Chem Int Ed Engl. 2022. PMID: 36089535 Free PMC article.

8

4-Oxo-β-Lactams as Novel Inhibitors for Rhomboid Proteases.

Yang J, Carvalho LAR, Ji S, Chen S, Moreira R, Verhelst SHL. Yang J, et al. Among authors: carvalho lar. Chembiochem. 2023 Nov 2;24(21):e202300418. doi: 10.1002/cbic.202300418. Epub 2023 Sep 15. Chembiochem. 2023. PMID: 37671979

9

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Falcão AS, Carvalho LA, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D. Falcão AS, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):89-99. doi: 10.1021/acschemneuro.6b00250. Epub 2016 Nov 15. ACS Chem Neurosci. 2017. PMID: 27797173

10

SMS-Split Muscle Support: A Reproducible Approach for Breast Implant Stabilization.

Rigo MH, Piccinini PS, Sartori LDP, de Carvalho LAR, Uebel CO. Rigo MH, et al. Among authors: de carvalho lar. Aesthetic Plast Surg. 2020 Jun;44(3):698-705. doi: 10.1007/s00266-019-01565-5. Epub 2019 Dec 16. Aesthetic Plast Surg. 2020. PMID: 31844946

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