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Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway.
Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ. Sofi MH, et al. Among authors: ogretmen b. Leukemia. 2022 Jul;36(7):1907-1915. doi: 10.1038/s41375-022-01581-6. Epub 2022 May 5. Leukemia. 2022. PMID: 35513703 Free PMC article.
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma.
Kang Y, Sundaramoorthy P, Gasparetto C, Feinberg D, Fan S, Long G, Sellars E, Garrett A, Tuchman SA, Reeves BN, Li Z, Liu B, Ogretmen B, Maines L, Ben-Yair VK, Smith C, Plasse T. Kang Y, et al. Among authors: ogretmen b. Ann Hematol. 2023 Feb;102(2):369-383. doi: 10.1007/s00277-022-05056-7. Epub 2022 Dec 3. Ann Hematol. 2023. PMID: 36460794 Clinical Trial.
Ceramide synthesis regulates T cell activity and GVHD development.
Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ. Sofi MH, et al. Among authors: ogretmen b. JCI Insight. 2017 May 18;2(10):e91701. doi: 10.1172/jci.insight.91701. eCollection 2017 May 18. JCI Insight. 2017. PMID: 28515365 Free PMC article.
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S. Chatterjee S, et al. Among authors: ogretmen b. Cell Metab. 2018 Jan 9;27(1):85-100.e8. doi: 10.1016/j.cmet.2017.10.006. Epub 2017 Nov 9. Cell Metab. 2018. PMID: 29129787 Free PMC article.
Mechanisms of Ceramide-Dependent Cancer Cell Death.
Nganga R, Oleinik N, Ogretmen B. Nganga R, et al. Among authors: ogretmen b. Adv Cancer Res. 2018;140:1-25. doi: 10.1016/bs.acr.2018.04.007. Adv Cancer Res. 2018. PMID: 30060806 Review.
Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.
Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu XZ. Nguyen H, et al. Among authors: ogretmen b. JCI Insight. 2018 Dec 20;3(24):e121697. doi: 10.1172/jci.insight.121697. JCI Insight. 2018. PMID: 30568037 Free PMC article.
146 results