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Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Cho Y, Chittoor G, Ahlskog R, Lind PA, Palviainen T, van der Zee MD, Cheesman R, Mangino M, Wang Y, Li S, Klaric L, Ratliff SM, Bielak LF, Nygaard M, Giannelis A, Willoughby EA, Reynolds CA, Balbona JV, Andreassen OA, Ask H, Baras A, Bauer CR, Boomsma DI, Campbell A, Campbell H, Chen Z, Christofidou P, Corfield E, Dahm CC, Dokuru DR, Evans LM, de Geus EJC, Giddaluru S, Gordon SD, Harden KP, Hill WD, Hughes A, Kerr SM, Kim Y, Kweon H, Latvala A, Lawlor DA, Li L, Lin K, Magnus P, Magnusson PKE, Mallard TT, Martikainen P, Mills MC, Njølstad PR, Overton JD, Pedersen NL, Porteous DJ, Reid J, Silventoinen K, Southey MC, Stoltenberg C, Tucker-Drob EM, Wright MJ; Social Science Genetic Association Consortium; Within Family Consortium; Hewitt JK, Keller MC, Stallings MC, Lee JJ, Christensen K, Kardia SLR, Peyser PA, Smith JA, Wilson JF, Hopper JL, Hägg S, Spector TD, Pingault JB, Plomin R, Havdahl A, Bartels M, Martin NG, Oskarsson S, Justice AE, Millwood IY, Hveem K, Naess Ø, Willer CJ, Åsvold BO, Koellinger PD, Kaprio J, Medland SE, Walters RG, Benjamin DJ, Turley P, Evans DM, Davey Smith G, Hayward C, Brumpton B, Hemani G, Davi… See abstract for full author list ➔ Howe LJ, et al. Among authors: hughes a. Nat Genet. 2022 May;54(5):581-592. doi: 10.1038/s41588-022-01062-7. Epub 2022 May 9. Nat Genet. 2022. PMID: 35534559 Free PMC article.
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.
Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie GÅ, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S; Within-family Consortium; 23andMe Research Team; Auton A, Windmeijer F, Chen WM, Bjørngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, Åsvold BO, Hemani G, Davies NM. Brumpton B, et al. Among authors: hughes a. Nat Commun. 2020 Jul 14;11(1):3519. doi: 10.1038/s41467-020-17117-4. Nat Commun. 2020. PMID: 32665587 Free PMC article.
Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study.
Hughes AM, Sanderson E, Morris T, Ayorech Z, Tesli M, Ask H, Reichborn-Kjennerud T, Andreassen OA, Magnus P, Helgeland Ø, Johansson S, Njølstad P, Davey Smith G, Havdahl A, Howe LD, Davies NM. Hughes AM, et al. Elife. 2022 Dec 20;11:e74320. doi: 10.7554/eLife.74320. Elife. 2022. PMID: 36537070 Free PMC article.
Looking at both child and adult genetics can help disentangle these processes. Hughes et al. show that a child's own body mass index, a ratio of weight and height, is not strongly associated with the child's mental health symptoms. ...These results contradict …
Looking at both child and adult genetics can help disentangle these processes. Hughes et al. show that a child's own body mass …
Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality.
O'Loughlin J, Casanova F, Fairhurst-Hunter Z, Hughes A, Bowden J, Watkins ER, Freathy RM, Millwood IY, Lin K, Chen Z, Li L, Lv J; China Kadoorie Biobank Collaborative Group; Walters RG, Howe LD, Kuchenbaecker K, Tyrrell J. O'Loughlin J, et al. Among authors: hughes a. BMC Med. 2023 Feb 1;21(1):37. doi: 10.1186/s12916-023-02735-8. BMC Med. 2023. PMID: 36726144 Free PMC article.
Intergenerational effects of parental educational attainment on parenting and childhood educational outcomes: Evidence from MoBa using within-family Mendelian randomization.
Havdahl A, Hughes AM, Sanderson E, Ask H, Cheesman R, Reichborn-Kjennerud T, Andreassen OA, Corfield EC, Hannigan L, Magnus P, Njølstad PR, Stoltenberg C, Torvik FA, Brandlistuen R, Smith GD, Ystrom E, Davies NM. Havdahl A, et al. Among authors: hughes am. medRxiv [Preprint]. 2023 Sep 21:2023.02.22.23285699. doi: 10.1101/2023.02.22.23285699. medRxiv. 2023. PMID: 36865116 Free PMC article. Preprint.
Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study.
Howe LJ, Rasheed H, Jones PR, Boomsma DI, Evans DM, Giannelis A, Hayward C, Hopper JL, Hughes A, Lahtinen H, Li S, Lind PA, Martin NG, Martikainen P, Medland SE, Morris TT, Nivard MG, Pingault JB, Silventoinen K, Smith JA, Willoughby EA, Wilson JF; Within Family Consortium; Åsvold BO, Næss ØE, Davey Smith G, Kaprio J, Brumpton B, Davies NM. Howe LJ, et al. Among authors: hughes a. Int J Epidemiol. 2023 Oct 5;52(5):1579-1591. doi: 10.1093/ije/dyad079. Int J Epidemiol. 2023. PMID: 37295953 Free PMC article.
BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study.
O'Loughlin J, Casanova F, Hughes A, Fairhurst-Hunter Z, Li L, Chen Z; China Kadoorie Biobank Collaborative Group; Bowden J, Watkins E, Freathy RM, Howe LD, Walters RG, Tyrrell J. O'Loughlin J, et al. Among authors: hughes a. Transl Psychiatry. 2023 Jul 11;13(1):251. doi: 10.1038/s41398-023-02539-7. Transl Psychiatry. 2023. PMID: 37433779 Free PMC article.
4,020 results