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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.
Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA. Mansurov A, et al. Among authors: chang k. Nat Biomed Eng. 2022 Jul;6(7):819-829. doi: 10.1038/s41551-022-00888-0. Epub 2022 May 9. Nat Biomed Eng. 2022. PMID: 35534574 Free PMC article.
Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity.
Slezak AJ, Mansurov A, Raczy MM, Chang K, Alpar AT, Lauterbach AL, Wallace RP, Weathered RK, Medellin JEG, Battistella C, Gray LT, Marchell TM, Gomes S, Swartz MA, Hubbell JA. Slezak AJ, et al. Among authors: chang k. ACS Cent Sci. 2022 Oct 26;8(10):1435-1446. doi: 10.1021/acscentsci.2c00704. Epub 2022 Oct 7. ACS Cent Sci. 2022. PMID: 36313164 Free PMC article.
Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.
Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Shim HN, Hultgren KT, Gomes S, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Kang S, et al. Among authors: chang k. Sci Adv. 2023 Dec;9(48):eadh9879. doi: 10.1126/sciadv.adh9879. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019919 Free PMC article.
Therapeutic synthetic and natural materials for immunoengineering.
Slezak A, Chang K, Hossainy S, Mansurov A, Rowan SJ, Hubbell JA, Guler MO. Slezak A, et al. Among authors: chang k. Chem Soc Rev. 2024 Feb 19;53(4):1789-1822. doi: 10.1039/d3cs00805c. Chem Soc Rev. 2024. PMID: 38170619 Free PMC article. Review.
Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy.
Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Berg BTK, Shim HN, Hultgren KT, Gomes S, Wang Y, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Kang S, et al. Among authors: chang k. J Immunother Cancer. 2024 Dec 22;12(12):e009541. doi: 10.1136/jitc-2024-009541. J Immunother Cancer. 2024. PMID: 39794939 Free PMC article.
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair.
Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. Lee K, et al. Among authors: chang k. Nat Biomed Eng. 2017;1:889-901. doi: 10.1038/s41551-017-0137-2. Epub 2017 Oct 2. Nat Biomed Eng. 2017. PMID: 29805845 Free PMC article.
Exosomes as promising frontier approaches in future cancer therapy.
Chew FY, Tsai CH, Chang KH, Chang YK, Chou RH, Liu YJ. Chew FY, et al. Among authors: chang kh. World J Gastrointest Oncol. 2025 Jan 15;17(1):100713. doi: 10.4251/wjgo.v17.i1.100713. World J Gastrointest Oncol. 2025. PMID: 39817143 Free PMC article.
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