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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.
Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA. Mansurov A, et al. Among authors: mendoza jl. Nat Biomed Eng. 2022 Jul;6(7):819-829. doi: 10.1038/s41551-022-00888-0. Epub 2022 May 9. Nat Biomed Eng. 2022. PMID: 35534574 Free PMC article.
Structure of the IFNγ receptor complex guides design of biased agonists.
Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.
Onabajo OO, Banday AR, Stanifer ML, Yan W, Obajemu A, Santer DM, Florez-Vargas O, Piontkivska H, Vargas JM, Ring TJ, Kee C, Doldan P, Tyrrell DL, Mendoza JL, Boulant S, Prokunina-Olsson L. Onabajo OO, et al. Among authors: mendoza jl. Nat Genet. 2020 Dec;52(12):1283-1293. doi: 10.1038/s41588-020-00731-9. Epub 2020 Oct 19. Nat Genet. 2020. PMID: 33077916 Free PMC article.
Deconstructing the peptide-MHC specificity of T cell recognition.
Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Birnbaum ME, et al. Among authors: mendoza jl. Cell. 2014 May 22;157(5):1073-87. doi: 10.1016/j.cell.2014.03.047. Cell. 2014. PMID: 24855945 Free PMC article.
Insights into cytokine-receptor interactions from cytokine engineering.
Spangler JB, Moraga I, Mendoza JL, Garcia KC. Spangler JB, et al. Among authors: mendoza jl. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Annu Rev Immunol. 2015. PMID: 25493332 Free PMC article. Review.
163 results