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Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Perković I, Raić-Malić S, Fontinha D, Prudêncio M, Pessanha de Carvalho L, Held J, Tandarić T, Vianello R, Zorc B, Rajić Z. Perković I, et al. Among authors: pessanha de carvalho l. Eur J Med Chem. 2020 Feb 1;187:111927. doi: 10.1016/j.ejmech.2019.111927. Epub 2019 Nov 29. Eur J Med Chem. 2020. PMID: 31812035
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.
Marinović M, Poje G, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Eur J Med Chem. 2021 Nov 15;224:113687. doi: 10.1016/j.ejmech.2021.113687. Epub 2021 Jul 5. Eur J Med Chem. 2021. PMID: 34274829
Novel Harmicines with Improved Potency against Plasmodium.
Marinović M, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Zorc B, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Molecules. 2020 Sep 23;25(19):4376. doi: 10.3390/molecules25194376. Molecules. 2020. PMID: 32977642 Free PMC article.
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Knaab TC, Held J, Burckhardt BB, Rubiano K, Okombo J, Yeo T, Mok S, Uhlemann AC, Lungerich B, Fischli C, Pessanha de Carvalho L, Mordmüller B, Wittlin S, Fidock DA, Kurz T. Knaab TC, et al. Among authors: pessanha de carvalho l. J Med Chem. 2021 Mar 25;64(6):3035-3047. doi: 10.1021/acs.jmedchem.0c01744. Epub 2021 Mar 5. J Med Chem. 2021. PMID: 33666415 Free PMC article.
Expanding the Chemical Space of Reverse Fosmidomycin Analogs.
Knak T, Takada S, Illarionov B, Krisilia V, Pessanha de Carvalho L, Lungerich B, Sakamoto Y, Höfmann S, Bacher A, Kalscheuer R, Held J, Fischer M, Tanaka N, Kurz T. Knak T, et al. Among authors: pessanha de carvalho l. ACS Med Chem Lett. 2024 Dec 23;16(1):136-143. doi: 10.1021/acsmedchemlett.4c00501. eCollection 2025 Jan 9. ACS Med Chem Lett. 2024. PMID: 39811140
TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance.
Knaab TC, Moritz A, Pessanha de Carvalho L, Klein S, Lungerich B, Lohse K, Kruse L, Mombo-Ngoma G, Orta L, Thibaud JL, de Villiers KA, Fidock DA, Burckhardt BB, Held J, Wittlin S, Kurz T. Knaab TC, et al. Among authors: pessanha de carvalho l. J Med Chem. 2025 Jan 9;68(1):95-107. doi: 10.1021/acs.jmedchem.4c01465. Epub 2024 Dec 26. J Med Chem. 2025. PMID: 39723908
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