Cayley AN - Search Results

1

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment.

Cayley AN, Foster RS, Hill E, Kane S, Kocks G, Myden A, Newman D, Stalford SA, Vessey JD, Zarei R, De Oliveira AAF. Cayley AN, et al. ALTEX. 2023;40(1):34–52. doi: 10.14573/altex.2201311. Epub 2022 May 13. ALTEX. 2023. PMID: 35575642 Free article.

2

Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained.

Barber C, Cayley A, Hanser T, Harding A, Heghes C, Vessey JD, Werner S, Weiner SK, Wichard J, Giddings A, Glowienke S, Parenty A, Brigo A, Spirkl HP, Amberg A, Kemper R, Greene N. Barber C, et al. Regul Toxicol Pharmacol. 2016 Apr;76:7-20. doi: 10.1016/j.yrtph.2015.12.006. Epub 2015 Dec 18. Regul Toxicol Pharmacol. 2016. PMID: 26708083

3

Utility of published DNA reactivity alerts.

Myden A, Guesne SJ, Cayley A, Williams RV. Myden A, et al. Regul Toxicol Pharmacol. 2017 Aug;88:77-86. doi: 10.1016/j.yrtph.2017.05.016. Epub 2017 May 23. Regul Toxicol Pharmacol. 2017. PMID: 28549899

4

Extrapolation of in vitro structural alerts for mutagenicity to the in vivo endpoint.

Tennant RE, Guesné SJ, Canipa S, Cayley A, Drewe WC, Honma M, Masumura K, Morita T, Stalford SA, Williams RV. Tennant RE, et al. Mutagenesis. 2019 Mar 6;34(1):111-121. doi: 10.1093/mutage/gey030. Mutagenesis. 2019. PMID: 30281100

5

The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7.

Foster RS, Fowkes A, Cayley A, Thresher A, Werner AD, Barber CG, Kocks G, Tennant RE, Williams RV, Kane S, Stalford SA. Foster RS, et al. Genes Environ. 2020 Sep 22;42:27. doi: 10.1186/s41021-020-00166-y. eCollection 2020. Genes Environ. 2020. PMID: 32983286 Free PMC article.

6

Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledge.

Ball T, Barber CG, Cayley A, Chilton ML, Foster R, Fowkes A, Heghes C, Hill E, Hill N, Kane S, Macmillan DS, Myden A, Newman D, Polit A, Stalford SA, Vessey JD. Ball T, et al. Toxicol Res (Camb). 2021 Jan 22;10(1):102-122. doi: 10.1093/toxres/tfaa099. eCollection 2021 Jan. Toxicol Res (Camb). 2021. PMID: 33613978 Free PMC article.

7

Employing an adverse outcome pathway framework for weight-of-evidence assessment with application to the ICH S1B guidance addendum.

Stalford SA, Cayley AN, de Oliveira AAF. Stalford SA, et al. Among authors: cayley an. Regul Toxicol Pharmacol. 2021 Dec;127:105071. doi: 10.1016/j.yrtph.2021.105071. Epub 2021 Oct 29. Regul Toxicol Pharmacol. 2021. PMID: 34737134

8

Assessing the utility of common arguments used in expert review of in silico predictions as part of ICH M7 assessments.

Cayley AN, Foster RS, Brigo A, Muster W, Musso A, Kenyon MO, Parris P, White AT, Cohen-Ohana M, Nudelman R, Glowienke S. Cayley AN, et al. Regul Toxicol Pharmacol. 2023 Oct;144:105490. doi: 10.1016/j.yrtph.2023.105490. Epub 2023 Aug 31. Regul Toxicol Pharmacol. 2023. PMID: 37659712

9

Risk assessment in the 21st century: where are we heading?

Brescia S, Alexander-White C, Li H, Cayley A. Brescia S, et al. Toxicol Res (Camb). 2023 Jan 10;12(1):1-11. doi: 10.1093/toxres/tfac087. eCollection 2023 Feb. Toxicol Res (Camb). 2023. PMID: 36866215 Free PMC article. Review.

10

Improvement of quantitative structure-activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project.

Honma M, Kitazawa A, Cayley A, Williams RV, Barber C, Hanser T, Saiakhov R, Chakravarti S, Myatt GJ, Cross KP, Benfenati E, Raitano G, Mekenyan O, Petkov P, Bossa C, Benigni R, Battistelli CL, Giuliani A, Tcheremenskaia O, DeMeo C, Norinder U, Koga H, Jose C, Jeliazkova N, Kochev N, Paskaleva V, Yang C, Daga PR, Clark RD, Rathman J. Honma M, et al. Mutagenesis. 2019 Mar 6;34(1):3-16. doi: 10.1093/mutage/gey031. Mutagenesis. 2019. PMID: 30357358 Free PMC article.

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