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Page 1
Multiple crystal forms of human MacroD2.
Wazir S, Maksimainen MM, Lehtiö L. Wazir S, et al. Acta Crystallogr F Struct Biol Commun. 2020 Oct 1;76(Pt 10):477-482. doi: 10.1107/S2053230X20011309. Epub 2020 Sep 15. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 33006575 Free PMC article.
Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication.
Mattila S, Merilahti P, Wazir S, Quirin T, Maksimainen MM, Zhang Y, Xhaard H, Lehtiö L, Ahola T. Mattila S, et al. Among authors: wazir s. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0139821. doi: 10.1128/AAC.01398-21. Epub 2021 Oct 4. Antimicrob Agents Chemother. 2021. PMID: 34606339 Free PMC article.
A molecular toolbox for ADP-ribosyl binding proteins.
Sowa ST, Galera-Prat A, Wazir S, Alanen HI, Maksimainen MM, Lehtiö L. Sowa ST, et al. Among authors: wazir s. Cell Rep Methods. 2021 Dec 20;1(8):100121. doi: 10.1016/j.crmeth.2021.100121. Epub 2021 Nov 11. Cell Rep Methods. 2021. PMID: 34786571 Free PMC article.
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.
Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Among authors: wazir s. bioRxiv [Preprint]. 2022 Mar 2:2022.03.01.482536. doi: 10.1101/2022.03.01.482536. bioRxiv. 2022. Update in: Antiviral Res. 2022 Jul;203:105344. doi: 10.1016/j.antiviral.2022.105344 PMID: 35262075 Free PMC article. Updated. Preprint.
Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: wazir s. bioRxiv [Preprint]. 2022 Feb 28:2022.02.27.482176. doi: 10.1101/2022.02.27.482176. bioRxiv. 2022. Update in: Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788 PMID: 35262078 Free PMC article. Updated. Preprint.
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: wazir s. Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788. Epub 2022 May 11. Bioorg Med Chem. 2022. PMID: 35597097 Free PMC article.
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Wazir S, et al. bioRxiv [Preprint]. 2023 Dec 27:2023.08.28.555062. doi: 10.1101/2023.08.28.555062. bioRxiv. 2023. Update in: J Med Chem. 2024 Apr 25;67(8):6519-6536. doi: 10.1021/acs.jmedchem.3c02451 PMID: 38234730 Free PMC article. Updated. Preprint.
101 results