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Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates.
Preston KB, Wong TAS, Lieberman MM, To A, Lai CY, Granados A, Thomasson H, Misamore J, Yalley-Ogunro J, Cabus M, Andersen H, Donini O, Lehrer AT, Randolph TW. Preston KB, et al. Among authors: to a. J Pharm Sci. 2022 Dec;111(12):3424-3434. doi: 10.1016/j.xphs.2022.05.017. Epub 2022 May 21. J Pharm Sci. 2022. PMID: 35609629
The vaccines, which contained a polysorbate 80-stabilized squalane-in-water emulsion adjuvant and were lyophilized from a solution containing trehalose, produced high antibody levels against all three filovirus antigens. ...Increases in squalane droplet sizes were o …
The vaccines, which contained a polysorbate 80-stabilized squalane-in-water emulsion adjuvant and were lyophilized from a solu …
Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice.
To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT. To A, et al. mSphere. 2018 Jan 10;3(1):e00576-17. doi: 10.1128/mSphere.00576-17. eCollection 2018 Jan-Feb. mSphere. 2018. PMID: 29359186 Free PMC article.
Following the 2015 Zika virus (ZIKV) outbreaks in the South Pacific, Caribbean, and Americas, ZIKV has emerged as a serious threat due to its association with infantile microcephaly and other neurologic disorders. Despite an international effort to develop …
Following the 2015 Zika virus (ZIKV) outbreaks in the South Pacific, Caribbean, and Americas, ZIKV has emerged as a serious threat du …
A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates.
Medina LO, To A, Lieberman MM, Wong TAS, Namekar M, Nakano E, Andersen H, Yalley-Ogunro J, Greenhouse J, Higgs S, Huang YS, Vanlandingham DL, Horton JS, Clements DE, Lehrer AT. Medina LO, et al. Among authors: to a. Front Immunol. 2018 Nov 8;9:2464. doi: 10.3389/fimmu.2018.02464. eCollection 2018. Front Immunol. 2018. PMID: 30467501 Free PMC article.
Zika Virus (ZIKV), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a public health threat following an epidemic in French Polynesia 2013-2014 that resulted in neurological complications associated with infectio …
Zika Virus (ZIKV), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a p …
Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays.
Preston KB, Monticello CR, Wong TAS, To A, Donini O, Lehrer AT, Randolph TW. Preston KB, et al. Among authors: to a. J Pharm Sci. 2020 Dec;109(12):3716-3727. doi: 10.1016/j.xphs.2020.09.011. Epub 2020 Sep 12. J Pharm Sci. 2020. PMID: 32931778 Free PMC article.
Lyophilized formulations and liquid controls were incubated for up to 12 weeks at 50 C to accelerate degradation. To identify a stability-indicating assay appropriate for monitoring protein degradation and immunogenicity loss during these accelerated s …
Lyophilized formulations and liquid controls were incubated for up to 12 weeks at 50 C to accelerate degradation. To id …
Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice.
Lai CY, To A, Wong TAS, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Donini O, Lehrer AT. Lai CY, et al. Among authors: to a. bioRxiv [Preprint]. 2021 Mar 3:2021.03.02.433614. doi: 10.1101/2021.03.02.433614. bioRxiv. 2021. Update in: Vaccine X. 2021 Nov 5:100126. doi: 10.1016/j.jvacx.2021.100126 PMID: 33688645 Free PMC article. Updated. Preprint.
We demonstrated that, when formulated with CoVaccine HTadjuvant, an oil-in-water nanoemulsion compatible with lyophilization, our vaccine candidates elicit a broad-spectrum IgG response, high neutralizing antibody titers, and a robust, antigen-specific IFN-gamma sec …
We demonstrated that, when formulated with CoVaccine HTadjuvant, an oil-in-water nanoemulsion compatible with lyophilization, our vaccine ca …
Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant.
Preston KB, Wong TAS, To A, Tashiro TE, Lieberman MM, Granados A, Feliciano K, Harrison J, Yalley-Ogunro J, Elyard HA, Donini O, Lehrer AT, Randolph TW. Preston KB, et al. Among authors: to a. Vaccine. 2021 Sep 15;39(39):5650-5657. doi: 10.1016/j.vaccine.2021.08.003. Epub 2021 Aug 13. Vaccine. 2021. PMID: 34400019 Free PMC article.
Previously, we showed that glycoprotein antigens from each virus could be lyophilized to create thermostable monovalent subunit vaccines. However, cross-protection is not expected from the monovalent vaccines and therefore developing a trivalent filovirus vaccine wo …
Previously, we showed that glycoprotein antigens from each virus could be lyophilized to create thermostable monovalent subunit vacci …
Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice.
Lai CY, To A, Ann S Wong T, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Furuyama W, Marzi A, Donini O, Lehrer AT. Lai CY, et al. Among authors: to a. Vaccine X. 2021 Nov 5;9:100126. doi: 10.1016/j.jvacx.2021.100126. Online ahead of print. Vaccine X. 2021. PMID: 34778744 Free PMC article.
Mass vaccination efforts using the highly effective vaccines are currently underway to generate sufficient herd immunity and reduce transmission of the SARS-CoV-2 virus. ...Dose response experiments indicated that NtAb titers increased with antigen dose, but not adjuvant d …
Mass vaccination efforts using the highly effective vaccines are currently underway to generate sufficient herd immunity and reduce t …
A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant.
To A, Wong TAS, Lieberman MM, Thompson K, Ball AH, Pessaint L, Greenhouse J, Daham N, Cook A, Narvaez B, Flinchbaugh Z, Van Ry A, Yalley-Ogunro J, Andersen Elyard H, Lai CY, Donini O, Lehrer AT. To A, et al. ACS Infect Dis. 2022 Apr 8;8(4):825-840. doi: 10.1021/acsinfecdis.1c00600. Epub 2022 Mar 9. ACS Infect Dis. 2022. PMID: 35263081 Free PMC article.
Here, we describe the durability and broad-spectrum VOC immunity of a prefusion-stabilized spike (S) protein adjuvanted with liquid or lyophilized CoVaccine HT in cynomolgus macaques. ...Protective efficacy and postexposure immunity were evaluated using a heterologo …
Here, we describe the durability and broad-spectrum VOC immunity of a prefusion-stabilized spike (S) protein adjuvanted with liquid o …
Adjuvants Differentially Modulate the Immunogenicity of Lassa Virus Glycoprotein Subunits in Mice.
To A, Lai CY, Wong TAS, Namekar M, Lieberman MM, Lehrer AT. To A, et al. Front Trop Dis. 2022;3:847598. doi: 10.3389/fitd.2022.847598. Epub 2022 Mar 10. Front Trop Dis. 2022. PMID: 37034031 Free PMC article.
Although several advanced vaccine candidates are progressing through clinical trials, some effective vaccines are virally vectored and thus require a stringent cold-chain, making distribution to rural and resource-poor areas difficult. ...Formulations with GPI-0100, …
Although several advanced vaccine candidates are progressing through clinical trials, some effective vaccines are virally vectored and thus …
Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection.
To A, Wong TAS, Ball AH, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Elyard HA, Borisevich V, Agans KN, Deer DJ, Woolsey C, Cross RW, Geisbert TW, Donini O, Lehrer AT. To A, et al. Vaccine. 2024 Jan 25;42(3):598-607. doi: 10.1016/j.vaccine.2023.12.053. Epub 2023 Dec 28. Vaccine. 2024. PMID: 38158300
Lyophilized formulations of the vaccines were reconstituted with Water for Injection and used to immunize groups of cynomolgus macaques before challenge with a lethal dose of a human SUDV or MARV isolate. ...Although mild, subclinical infection was observed i …
Lyophilized formulations of the vaccines were reconstituted with Water for Injection and used to immunize groups of cynomolgus macaqu …
214 results